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Cannabis May Lead to An Alteration in the Sperm’s Gene for Autism

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Autism

A recent study suggests that using cannabis may lead to an alteration in the sperm’s gene for autism. The journal Epigenetics has published this study. And it states that cannabis can bring about changes in the DLGAP2 gene in men’s sperm.

The results of the study have shown that changes in this gene take place by a process known as DNA methylation. And it has the potential to pass on to the next generation.

Using cannabis can bring changes in the methylation of DLGAP2 gene

Nowadays, many countries have legalized the use of recreational and medical cannabis. But the use of cannabis in parents may affect the nervous system of the offspring and cause conditions like autism. The fathers who use cannabis may be using them for two.

This study includes 24 men and 15 rats. And it highlights the ability of marijuana to affect the next generation. The research team has detected a significant hypomethylation at the DLGAP2 gene in the sperm of men who have used cannabis compared to the non-users.

The finding was similar in the case of mice exposed to THC (tetrahydrocannabinol). The rats born to fathers subjected to THC also had this hypomethylated state in their forebrain. These results may provide little evidence that cannabis can lead to an alteration in the sperm’s gene for autism.

Also related- These trials will help us know if Marijuana has the capacity to treat Autism

The research team has stated that these results do not define an obvious relation between the use of cannabis and autism. But still, this possible link stresses the need for further study. The team has used quantitative bisulfite pyrosequencing to validate the differential methylation in the DLGAP2 gene for the nine CpG sites in intron seven.

The DNA methylation at the DLGAP2 gene was present in the sperms of male rats exposed to THC. Moreover, the accumbens nucleus of their offspring has also shown the presence of methylation.

DNA methylation can cause a reduction in the expression of DLGAP2

In an earlier study, the research team found many changes in the gene of men’s sperm who smoked marijuana. On the contrary, this recent study has focused on specific genes, especially DLGAP2.

DLGAP2 means Discs-Large Associated Protein 2. DLGAP2 is a gene implicated in autism. And it is involved in neural signaling and the organization of synapse. Besides its link with autism, this gene is also related to PTSD and schizophrenia.

Other discoveries from this study involve a sex-based difference in the link between DNA methylation and gene activity in human brain tissues. In both sexes, there was a decrease in gene activity with an increase in DNA methylation.

But this link was strongest in females, and less maintained in males. At present, the exact reason for this difference is unknown. This variance in both sexes was significant, as the ratio of boys to girls with autism is 4:1.

The association between methylation and the expression of gene changes if the methylation change is passed along to offspring. But the fact that DLGAP2 gene in sperm is functionally important in the brain is clear, in any event. This is the first study that has shown the relation between cannabis use in men and autism in offspring.

It indicates that use the cannabis may lead to an alteration in the sperm’s gene for autism. But due to the small sample size (24 men), this study hasn’t accounted for the confounding factors. And still, these factors like sleep, diet, and physical activity may affect the study results.

 

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Can Cannabis Withdrawal Affect Mental Health?

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People often contrast cannabis to be more addicting in psychological manner than physical manner. Science does not prove that perception. With the endocannabinoid system, physical addiction symptoms of cannabis withdrawal might appear.

Around 10 percent of the cannabis users develop an addiction for cannabis. The number is far lesser than the harmful substances like nicotine where the addiction rate is 32 percent.

Other substances like alcohol also have a higher addiction rate; 15 percent.

This points to the fact that cannabis addiction is not only rarer but also less harmful. Psychological management of cannabis addiction is much easier than the management for alcohol addiction. This is because according to studies death rates in cannabis addicts are much lower than alcohol addicts.

However, it does not mean that cannabis addiction is a joke. Moreover, some people have reported addiction and withdrawal symptoms of using cannabis through experience.

Do people generally feel an addiction with regular use?

Most of the people even with regular use of cannabis do not feel the addiction in severe modes. It is easy for them to drop the substance whenever they want to. Moreover, it is easier for them to go days without cannabis in comparison to other drugs.

The idea of cannabis addiction has gone mainstream and more people are starting to accept it with rising use of cannabis. The widespread legalization has also made them aware. However, some doctors believe that cannabis does not cause physical addiction.

With the California’s Proposition 19, the statement officially came forward that further proved the fact. The advocates supported the idea that the substance does not cause physical addiction.

With much polarization, the current state of affairs remains undecided. However, there are both sides of the story as certain elements point to both pros and cons of the matter.

Some people are of the opinion that cannabis advocates do not want to highlight the cons of cannabis and thus do not mention its addiction effects.

What does a public survey suggest?

A survey of Washington cannabis consumers depicted that around 17 per cent people thought cannabis to be addictive. This was the same statistics with the people who were cannabis addicts. On the other hand, 50 per cent of the cannabis users thought that the substance was not addictive.

However, the bright side of the story shows that the withdrawal symptoms of cannabis are not as harmful as other withdrawals. People who reportedly withdraw using nicotine show more problematic behavioral and physical effects. The same situation occurs in people who leave alcohol for good.

These symptoms include the dangerous seizures, tremors and even delirium situations. Whereas, some people on withdrawing the substance also showed flu like symptoms. This more often resulted through withdrawal of opioids.

However, there is a need for more research on the effects of withdrawal of cannabis on the physical health of the people. With more focus on cannabis addicts and their comparison with other addicts, this can be easy and practical.

Scientists are now starting to look at different behavioral and physical prospects of cannabis addiction and withdrawal.

 

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Should You Dare Orally Consuming Pure Cannabis?

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Cannabis alludes to the dried stems, blossoms, leaves and seeds of the Cannabis sativa and Cannabis indica plants. In any case, not all individuals can smoke or utilize a vape, which beseeches a few people to ask if consuming pure cannabis via mouth is harmless? Apparently, yes.

Much like its cousin plant hemp, marijuana-imbued items are plentifully available. They incorporate caffeinated drinks, chewy candies, containers, teas, oils, tinctures, and edibles. The vast majority of these items previously came into the market as far back as the 1960s. There are likewise non-palatable marijuana items like salves and creams.

The opinion differs from state to state

An expression of alert, the lawfulness of these marijuana-imbued items differ from state to state, and what’s lawful in one spot might be a government offensive in the other. So research ought to be guaranteed.

The ultimateness itself of marijuana is generally in the dark area, contingent upon the state and nation. Weed is the dried pieces of a plant, so yes you can eat it crudely.

Notwithstanding, marijuana needs to experience a procedure called decarboxylation to initiate its psychoactive properties. Also, it won’t have a similar impact as real marijuana items.

That is because even though marijuana as of now contains CBD and THC, they should initially be warmth treated to transform into dynamic mixes. While eating it crude won’t give similar impacts, a few specialists trust that there is variety of plant mixes. Also, doing as such will at present give some medical advantages.

However, there is a need to do more research on the subject to find its further benefits. CBD has benefits in almost all kinds of industries like medicines for inflammation, chronic pain, multiple sclerosis, arthritis, chemotherapy nausea, epilepsy and others. It has also been proved to relieve anxiety.

Also, it has found uses in replacement therapy and others. Harvard Medical School states its seizure alleviating properties.

Moreover, CBD has a high potential to address the problem right at hand. It can also normalize the immune function at the target area. Medical marijuana is getting the same popularity as a magic pill, if not more. With a little research, scientists have collected a lot of evidence on the wonders it can do including mental and physical health problems.

Legalization issue in different perspectives

With the CBD regulation issue resolved all over the states, there will be more comfortable for the brands. The U.S President recently signed the Farm Bill according to which the Federal Government will allow the production, growth, and distribution of CBD in the last month of this year.

On the other side of the news, the Food and Drug Administration has not officially fully regulated cannabis-infused products in the market yet. However, it is planning to have public hearings on this matter next month.

The underlying issue lies in its dosage. The concentration of the psycho active compound, THC, is crucial in determining the appropriate intake of cannabis. The method of consumption of pure cannabis also has a critical role in determining the activity of cannabis in the body.

 

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Time to Replace Your Chewing Gums With Cannabis Strips!

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With the growth of the cannabis industry, there are new methods of consumption coming around. These methods have surpassed the once trendy joints and edibles. You can have a tiny film of cannabis under your tongue now. These cannabis strips are becoming quite trendy now in the emerging industry.

The characteristics that include uniqueness and efficiency are what make them stand out from the crowd.

What is the mechanism of action for these strips?

The strips interact directly with the saliva-producing membranes present in the oral cavity of a person. These membranes are resistant to wear and tear and are able to regenerate their cells at a fast pace. They have many functions. The biggest function is being a barrier and shielding the tissues of the oral cavity from microbes that might enter the oral cavity.

The mucosal membrane is also responsible for sensitization of the oral cavity which helps in eating. In addition to that, it also keeps the cavity moist to provide lubrication for easy chewing.

Why is the oral cavity absorption mechanism so highlighted?

Many scientists have used this membrane as a means to dose people with specific pharmaceutical products. It is because this membrane is highly permeable to certain molecules.

The main cause of sublingual absorption popularity among cannabis users is the efficient result that it offers to the users. Moreover, the patient will have a dose of the substance without getting any smoke. The onset is quite rapid and consistent in comparison to edibles as well.

This method of absorption skips the absorption process through the gastrointestinal system. This is a crucial step because in the GI tract the acids and enzymatic actions convert the THC into a more potent psychoactive form which can make a person get high.

This way, medical patients won’t have to get scared of the psychoactive side effects of consuming cannabis edibles through the GI route. Also, they would get twice the efficiency in half the time.

What is the right method of consuming cannabis strips?

However, you will have to keep this in mind that you need to keep the strip right under your tongue, where the sublingual gland is present. You will not get optimal results if you keep the film over your tongue.

Many cannabis users do not get the require results because they keep placing the film on their tongues. This is because many people mistake them for breath strips. Both are totally different products and have a different mechanism of action.

When you place the product under your tongue, keep your mouth closed for around five minutes. The product will get dissolved and provide with the beneficial results that you want.

The dissolving capability of these strips varies from brand to brand. Some take a minute to dissolve, while some take a few more minutes. However, experts suggest waiting for 5 minutes to get beneficial effects. If you do not wait after placing the strip and continue talking, chances are, the mechanism of action might get disturbed.

 

 

 

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