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Cannabis, A Potential Treatment for MRSA?

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A paper was recently published by researchers at McMaster University in Canada, describing how cannabigerol potentially killed various strains of MRSA – the antibiotic-resistant staph bacteria. The team of researchers led by Eric D. Brown had taken a step further from the petri dish and started testing CBD on rodents. Their results could potentially be the first step in an attempt to make CBG the newest antibiotic in the market.

MRSA in hospitals

MRSA is an infection of the skin and soft tissues, which causes red pus-filled bumps and sores. While MRSA is not an infamous problem in hospitals worldwide, staph bacteria ( Staphylococcus aureus) is carried by one in three people in their nose. Although a common bacteria, unless it enters an open wound – which could lead to a sometimes deadly infection, it is generally harmless.

Antibiotics can successfully treat most staph infections, but antibiotic-resistant staph, known as MRSA, has proven to be dangerous. MRSA can be carried by 5 in 100 people. Although they are generally mild infections, difficulty in treatment has been shown. MRSA could potentially prove to be fatal for people with suppressed immune systems in hospitals.

Cannabis – An antibacterial agent

Cannabis has been known for its antibacterial properties. While early researchers had some ambiguity regarding the active specific compounds, recent research has been able to recognize which cannabinoids are effective against which bacteria.

When 18 cannabinoids were tested against common strains of MRSA by the McMaster University team, almost all of them had shown some efficacy against the bacteria. Most effectiveness was shown by seven cannabinoids including CBG, CBD, CBN, CBCA, Δ9-THC, and Δ8-THC. They were able to kill the bacteria at concentrations that were low enough to warrant further investigation. Moreover, CBG showed efficacy at specifically low concentrations.

CBG to kill MRSA

The biofilm that bacterial cells develop for protection makes MRSA difficult to treat. However, it appears that CBG is able to strip away MRSA’s biofilm, also leaving our blood cells’ defenses intact.

CBG helps prevent the formation of the biofilm, while also being able to strip it away. That is probably the reason that even low concentrations of CBG are effective at killing MRSA.

The question, however, is, whether CBG would do the same to blood cells. Such reactions would be a major signal to halt further research. However, researchers have reported healthy human red blood cells even after the exposure to CBG.

Treatment of MRSA in Humans

Conventionally in drug evolution, a compound is tested on animals, only after it has shown efficacy in a petri dish. The McMaster researchers treated mice with CBG and concluded that it reduced the animals’ bacterial load by half.

100mg/kg of injected CBG was proven to be the most effective dose to kill bacteria. Scaling it to human size, it would be a hefty dose. It would roughly be a quarter-ounce of puer CBG for a 154-pound human. Additionally, the general medical applications of cannabinoids have been oral, oromucosal, or intranasal, and not injected.

The Balance of Efficacy and Safety

According to researcher Eric D. Brown, despite the generally high doses of antibiotics compared to other medications, the need for safety and tolerability has to be taken under consideration when talking about the need for high doses of antibiotics to achieve efficacy. He further added how this is one of the reasons for failure in antibiotic drug discovery and development. He believes the balance between efficacy and tolerability is hard to achieve and which is why MRSA remains a problem. However, it may not be too far-fetched to envision a day when we can use CBG for the treatment of MRSA.

 

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Study Reveals Vaping Cannabis Is More Lethal Than Smoking For Teenagers

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Cannabis vaping

Everyone knows vaping damages the lungs of individuals. But a recent study suggests that vaping cannabis damages the lungs of teenagers more than vaping tobacco. The risk of lung injury increases in individuals between the ages of 12 to 17 years old if they have a habit of vaping cannabis.

The lung injury causes difficulty in breathing, whistling, and wheezing. Moreover, due to difficulty in breathing, teenagers become unable to perform day-to-day activities. According to the study, teenagers who vape cannabis have a doubled risk of developing lung injuries than teens who smoke or use e-cigarettes. 

Research Regarding Vaping Cannabis 

The research leader was Carol Boyd, and it occurs in collaboration with the University of Michigan. Carol Boyd is a professor at the university’s School of Nursing. Boyd is co-director of the University of Michigan’s Center for the Study of Drugs, Alcohol, Smoking, and Health.

According to Boyd, smoking cigarettes or e-cigarettes is unhealthy for health, but vaping cannabis is more damaging than both. 

ALSO READ: Cannabis Industry, Celiac Disease, And Processed Flour

The researchers did not note whether teens consumed legal cannabis or not. Thousands of participants between 12 to 17 ages were surveyed for the research study. Furthermore, the participants themselves reported symptoms of lung injury in the Population Assessment of Tobacco and Health Study. 

Moreover, the researchers discovered that cigarettes and e-cigarettes do not cause respiratory illness and injury. However, the research does not focus on the effect generated by vaping cannabis and tobacco together. 

Survey Findings

According to survey-based research, teenagers who vape cannabis have an 81% greater risk of wheezing or whistling in the chest. The increase in wheezing is observable in cigarette and e-cigarette users as they exhibit a 15% raise, and a 9% rise in the risk of wheezing, respectively. 

Apart from the increase in whistling teens, they also experience other changes due to vaping cannabis. Teenagers who are habitual of vaping marijuana suffer 71% sleep disturbances due to wheezing while sleeping. 96% speech limitations, 33% wheezing during exercise, and 26% dry coughing at night occur in teens that vape cannabis. The overall health condition of teenagers gets worse with vaping cannabis. Smoking and e-cigarettes also damage the lungs, but the effects of vaping marijuana are more severe.  

Moreover, the use of vaping devices has increased, and so have the mysterious lung illnesses. Furthermore, before the coronavirus pandemic, the deaths of individuals due to cannabis vaping increased. It results in the downfall of vaping industry. 

What Do Others Have To Say About Vaping Cannabis?

The Centers for Disease Control and Prevention noted that vitamin E acetate is present in all teenagers with a mysterious lung illness-causing respiratory symptoms. Moreover, vitamin E acetate is a constituent of the e-liquids containing THC, called EVALI. Thus, vaping marijuana is a cause of lung injury leading to wheezing during exercise and other symptoms of lung-illness. 

Furthermore, individuals that have lung injuries contain Vitamin E acetate in their pulmonary fluid. According to Boyd, vaping-associated lung injuries and vitamin E acetate have a link to one another.  

ALSO READ: U.S. States Most Likely To Legalize Cannabis Recreational Use

Michael R. Bloomberg is the founder and majority owner of Bloomberg News. Michael R. Bloomberg opposes vaping of cannabis and tobacco. Moreover, Bloomberg has organized campaigns and gives money for banning e-cigarettes and tobacco-vaping in the U.S. 

According to Dr. Albert Rizzo, the FDA does not ensure that cannabis products and e-cigarettes contain the ingredients mentioned on the label. Moreover, according to Rizzo, individuals and teens vaping cannabis and tobacco are at the mercy of the manufacturer.

Furthermore, Rizzo criticizes that the manufacturers of cigarettes, e-cigarettes, and vaping devices are not providing FDA sufficient data. They are not removing products from the market as per prior decisions. 

According to Rizzo, researchers must focus on the effects of inhaling substances and vaping devices on lung conditions. 

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CBD Oil Solutions To Many Pandemic Mental Health Issues

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CBD for stress

In 2020, due to the coronavirus pandemic, individuals with mental health issues, particularly anxiety and stress patients, have increased. A study suggests CBD Oil heals and reduces anxiety issues. 

Individuals take time to understand and accept changes. Therefore, immediate or sudden alterations in life increase anxiety risk. The coronavirus pandemic has forced individuals to make abrupt changes and adapt to new circumstances. Because of it, individuals feel exhausted, under pressure, stress and also experience episodes of anxiety and depression.

To uplift mental health, a Canadian company CBD2HEAL is working and researching to form new CBD (Cannabidiol) products. Individuals can do various things to improve their mental health condition. They can try exercising, gardening, or caring for a plant, eat healthily, find new hobbies, and use high quantity CBD oil. 

ALSO READ: Know Doctors Recommended Marijuana Tips

Various products contain CBD and perform different functions. Some formulations contain CBD to reduce pain, while some products contain-CBD to give anxiety relief. The individuals can use these products to relieve stress and deal with anxiety, which is vital for many due to stressful pandemic situations.

Work From Home, COVID-19, and Use Of CBD 

Individuals during the coronavirus pandemic have to spend most of their time at home; they were to work from home, which had its pros and cons. Working from home does enable employees to work freely without getting formally dressed. In addition, with this, the individuals can form their comfortable working environment to focus more on their tasks.

However, the majority states otherwise as most of the individuals face difficulty in concentrating at work from home. This is because many individuals have reported to build a habit of scrolling social networking sites before initiating work. 

The difficulty in concentrating affects work performance but there is nothing to worry about as one can use Cannabidiol products that can improve the focus and concentration. Moreover, cannabis containing CBD edibles contains THC in normal concentration so that it does not cause individuals to become high. 

CBD Oil To Reduce Anxiety 

It is vital to treat diseases and disorders whether they are physical ones or psychological ones. Leaving mental health issues unchecked can worsen the condition. Also, untreated mental disorders may lead to death. 

Thus, individuals must treat their stress and anxiety issues as soon as possible. Moreover, anxiety can lead to depression and suicide if left untreated for longer durations. Individuals can use CBD oil to reduce stress and achieve mental peace. Some individuals, in an attempt to reduce stress and anxiety, start drinking alcohol, smoking, and other unhealthy habits. An unhealthy lifestyle can further make the condition of such individuals worse. 

Using CBD products to lower stress and anxiety is effective and safe. The plus point is that individuals do not experience withdrawal-symptoms with the use of CBD products for treating and reducing stress. CBD products for stress reduction are easy to consume like a daily supplement.

ALSO READ: Cannabis Sales Reaches Skies, Set Highest Mark With $17.5 Billion Sales

Does Cannabidiol Products Effect Sleep?

Sleep is essential for health and bodily functions as, during sleep, the body repairs itself. Not enough bedtime rest increases the risk of developing the psychological condition. 

During the coronavirus pandemic, individuals were unable to get eight hours of continuous sleep. Thus, the daily routine was upside down without a proper schedule. It is a matter of fact that people with anxiety issues are unable to get sufficient sleep. If individuals use CBD-oil then there are high chances that the anti-anxiety effect of CBD-oil will decrease symptoms of insomnia resulting in better quality sleep. 

In a nutshell, CBD products aids individuals in relaxing and sleeping. The relaxing effect enables to lower stress levels and also improve quality of sleep. To lead a healthy life, experts also recommend avoiding excessive use of mobile phones and electronics. It is beneficial for healthy sleep to stop using electronics two hours before bedtime. 

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Know Doctors Recommended Marijuana Tips

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Marijuana Legalization

With the increasingly legal use of marijuana across the country, Americans are wandering about cannabis products. Marijuana is legalized for medical and adult-use in a state, thereby easily accessible for one-third of Americans. 

The use of marijuana in medication opens doors to a better understanding of the drug. Moreover, it allows building a healthy relationship between patient and physician. The increasing legality of marijuana utilization permits people to have a heart-to-heart conversation with their health care providers.  

Counseling By Physician 

With the legalization of marijuana medical use, you can consult your healthcare provider without any reluctance. The use of cannabis products in medications gives you a platform to feel free to have a conversation about the drug and extract essential information from a trustworthy source. 

An experienced healthcare provider can assist you in choosing the right cannabis product and its safe consumption or whether you should go for marijuana therapy or not. A knowledgeable physician guides you with a safe dose of cannabis products that won’t influence your lifestyle. 

ALSO READ: Texas Med Store Starts Selling Cannabis-Infused Gummies As Medical Marijuana

So, you don’t have to feel ashamed or afraid of talking about cannabis products with your healthcare provider. One possibility lies that your physician may refer you to some other healthcare provider if he is not comfortable talking about marijuana recreational and medication use and its influence on your health and lifestyle. 

Essential Information About Marijuana

Cannabis legalization in your state allows you to extract more about the drug, and consulting your physician is a good go-ahead. It also permits its consumption legally.

Considering State’s Law Regarding Marijuana

Marijuana will be a patchwork of legality, until or unless the federal government steps forward. State laws are altering without many delays, stimulated by legislators, constituents, consumption, and customer demands.

Sneak into what your state’s law considers legal before researching cannabis anymore. To gather more information about cannabis-containing items, ask the health department in your state.

Eloise Theisen tells Verywell that according to the law of the state, each cannabis program has a specific administration guideline and some of the programs are more restricted than others. 

 However, patients are not permitted to travel out of state carrying cannabis products, as marijuana comes under the Schedule I drug. Moreover, she says that it might be distressing for the patients to rely on marijuana instead of pharmaceuticals for symptomology management. If you are hoping to travel in the future, ask your physician for a modified therapy regimen. 

Get A Glimpse In Your Employee Handbook

Detailed drug policies are given by some employers, industries, or unions. Furthermore, these drug policies don’t discriminate between medical and adult use. Ultimately, the drug tests will be positive. 

On account of state legality, certain employers do not conduct the testing of marijuana. According to Theisen, if there is a risk of job termination due to a positive drug test, then the efficacy of the treatment is reconsidered.

Get Educated About Your Treatment Regimen

Rahul Khare, MD, advises being confident when having a conversation about cannabis products with your healthcare physician. Fearlessly ask about your cannabis treatment plan, as there is no shame in being concerned about your health and hoping to feel better, so feel free to talk about marijuana use. 

Cannabis products are prioritized when the patient is reluctant to use opioids. If the patient is lagging in support and education due to physician negligence, seek guidance from some other medical provider. 

Make Some Effort At Your Edge

According to Khare, verbal communication is how many consider medical cannabis. Although personal anecdotes leave no margin of doubts, it’s crucial to consider the source and step into your research concurrently. 

Khare states that dispensaries are informative, but Google Scholars can help study thousands of cannabinoids. However, these practices are not an alternative to professional consultation. Your medical professional can translate research findings for you, elaborate biological mechanisms, and learn about your health conditions. 

Afraid Of Getting High

Theisen states that most of the patients are afraid of using high doses of cannabinoids. A major misconception about the use of cannabis products is that they end up with psychosis or hallucinations at higher doses. However, it is happening very rarely. 

On the contrary, some patients may feel euphoric. The euphoric condition is fruitful for those who are suffering from stress, depression, and anxiety. 

Marijuana Consumption Calls For Your Intentionality 

Cannabis remains a drug even though it is legal for adult-use or medical purposes, for instance, to relieve nausea from chemotherapy. Leslie Mendoza Temple, MD, says that the outcomes obtained by cannabis consumption are highly dependent on your intentions.  

Therefore, Temple emphasized having an open conversation with your physician, as it will help in extracting optimal benefits and avoid substance misuse. 

Unveiling Endocannabinoids System 

In 1990s, researchers came up with the Endocannabinoid System. This system has been playing a vital role in various bodily functions. The system consists of endocannabinoids, cannabinoid receptors (CB1 and CB2), and enzymes. Cannabinoid enzymes are responsible for the decomposition of naturally occurring cannabis-like substances in the body. 

Moreover, this system regulates appetite, digestion, immune function, and inflammation. The endocannabinoid system is responsible for regulating mood, sleep-wake cycles, fertility, pain, pleasure, and motor control. 

Consequently, medication and recreational use of cannabis is legalized by the state, as cannabis plays a leading role in the regulation of this system. 

Eradicating Illicit Consumption Of Marijuana

Concerning the integrity of cannabis products, these programs are highly under state regulation, as the dispensary and cultivator are to cling to strict standards. 

Until the legalization of cannabis products, the product’s safety was not a concerning issue. According to recommendations, you must go straight to the source if you desire to consume cannabis products. According to Temple, it is best to get marijuana products from a dispensary that has state approval to ensure there is nothing illegal.

Staying Slow And Steady Is The Key

Healthcare professionals recommend an initial low dose of the drug and increase it gradually while monitoring its impact on the patient’s body. Temple states that like many medications, cannabis products must be consumed at a low dose initially. Moreover, initial low doses are for avoiding unpleasant drug effects. 

ALSO READ: Follow New Proposition 65 For Cannabis Or Pay Penalties In California

Moreover, Temple advises the patients to never finish their whole candy bar in a single sitting and be intentional of the size serving or the packaging of the dosage. In a nutshell, follow your physician guidelines, budtender, or cannabis concierge to avoid harmful impacts. 

Begin With Comfort

Temple and Theisen recommend topicals, tinctures, and edibles are for first-time users on account of ease in control and administration. 

Topical dosage forms are applicable on the skin from where absorption of the medication occurs, for instance, lotions, creams, and oils. 

Tinctures are similar to the liquid medicines that come in bottles with droppers for precise administration. Individuals use droppers to administer cannabis-tinctures and administer tinctures precisely under the tongue.

Edibles have a longer-onset of action as they take time during chewing and digesting. Moreover, their absorption into the bloodstream is also a slow process. 

 

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