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Cannabis, A Potential Treatment for MRSA?

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A paper was recently published by researchers at McMaster University in Canada, describing how cannabigerol potentially killed various strains of MRSA – the antibiotic-resistant staph bacteria. The team of researchers led by Eric D. Brown had taken a step further from the petri dish and started testing CBD on rodents. Their results could potentially be the first step in an attempt to make CBG the newest antibiotic in the market.

MRSA in hospitals

MRSA is an infection of the skin and soft tissues, which causes red pus-filled bumps and sores. While MRSA is not an infamous problem in hospitals worldwide, staph bacteria ( Staphylococcus aureus) is carried by one in three people in their nose. Although a common bacteria, unless it enters an open wound – which could lead to a sometimes deadly infection, it is generally harmless.

Antibiotics can successfully treat most staph infections, but antibiotic-resistant staph, known as MRSA, has proven to be dangerous. MRSA can be carried by 5 in 100 people. Although they are generally mild infections, difficulty in treatment has been shown. MRSA could potentially prove to be fatal for people with suppressed immune systems in hospitals.

Cannabis – An antibacterial agent

Cannabis has been known for its antibacterial properties. While early researchers had some ambiguity regarding the active specific compounds, recent research has been able to recognize which cannabinoids are effective against which bacteria.

When 18 cannabinoids were tested against common strains of MRSA by the McMaster University team, almost all of them had shown some efficacy against the bacteria. Most effectiveness was shown by seven cannabinoids including CBG, CBD, CBN, CBCA, Δ9-THC, and Δ8-THC. They were able to kill the bacteria at concentrations that were low enough to warrant further investigation. Moreover, CBG showed efficacy at specifically low concentrations.

CBG to kill MRSA

The biofilm that bacterial cells develop for protection makes MRSA difficult to treat. However, it appears that CBG is able to strip away MRSA’s biofilm, also leaving our blood cells’ defenses intact.

CBG helps prevent the formation of the biofilm, while also being able to strip it away. That is probably the reason that even low concentrations of CBG are effective at killing MRSA.

The question, however, is, whether CBG would do the same to blood cells. Such reactions would be a major signal to halt further research. However, researchers have reported healthy human red blood cells even after the exposure to CBG.

Treatment of MRSA in Humans

Conventionally in drug evolution, a compound is tested on animals, only after it has shown efficacy in a petri dish. The McMaster researchers treated mice with CBG and concluded that it reduced the animals’ bacterial load by half.

100mg/kg of injected CBG was proven to be the most effective dose to kill bacteria. Scaling it to human size, it would be a hefty dose. It would roughly be a quarter-ounce of puer CBG for a 154-pound human. Additionally, the general medical applications of cannabinoids have been oral, oromucosal, or intranasal, and not injected.

The Balance of Efficacy and Safety

According to researcher Eric D. Brown, despite the generally high doses of antibiotics compared to other medications, the need for safety and tolerability has to be taken under consideration when talking about the need for high doses of antibiotics to achieve efficacy. He further added how this is one of the reasons for failure in antibiotic drug discovery and development. He believes the balance between efficacy and tolerability is hard to achieve and which is why MRSA remains a problem. However, it may not be too far-fetched to envision a day when we can use CBG for the treatment of MRSA.

 

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Receptra Naturals offers 50% Off CBD Products as Military Appreciation Program

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CBD Sale

As a part of the Military Appreciation Program, Receptra Naturals decided to provide a 50% discount on CBD products for veterans. Founded in 2015, Receptra Naturals has always believed in empowering oneself with well-deserved relief, rest, and relaxation. Their CBD and hemp products come with a promise of quality and authenticity, as they strive to build trust for their consumers.

Receptra Naturals is devoted to reliability and effectiveness for their cannabis products, to help with the issues faced by thousands of people. Their hemp is locally grown with organic farming practices, allowing them to extract only the most beneficial part of the plant. Moreover, their hemp is specially hand-shucked from their very own family-owned farm.

The extract is then combined with organic and natural ingredients, and botanicals only, which further enhances the effectiveness of the hemp product. Furthermore, their CBD products are also completely natural and plant-based, with the inclusion of organic ingredients, greatly emphasizing the transparency and quality of the final product.

Receptra Naturals don’t ignore the importance of authenticity to help consumers be confident in the quality and effectiveness when purchasing the cannabis product. Hence, they also offer third-party examinations for each of their cannabis products.

Owing to their reliability and devotion, they are also internationally acclaimed with their availability in all 50 states, along with multiple countries globally, diverging into thousands of retailers and online. Moreover, many influential platforms such as USA Today, Forbes, LA Weekly, and various other notable resources, acknowledged Receptra Naturals as a trusted source for CBD products. . Here are 5 best CBD products that you need to try –

Serious Relief + Turmeric Tincture

Receptra Naturals

  • Sizes – 0.5oz, 1oz, 2oz
  • Dosage – 33mg/dose
  • Recommended Use – 1 full dropper for adults, 1-3 times a day. Before swallowing, place the contents under your tongue for 20 seconds.
  • 30-Day Satisfaction Guarantee

The Serious Relief + Turmeric Tincture has been created with the perfect blend of organic and natural ingredients only. The careful selection of ingredients in the perfect ratio, help recovery, and provide relief from discomfort, physical demands, etc. Moreover, it consists of 33mg of full-spectrum CBD hemp extract in one full dropper, which is the recommended amount of CBD to help increase recovery rate and relief from multiple ailments.

The essential ingredients in the tincture are omega 3 and 6 fatty acids, MCT oil, avocado oil, and turmeric. This ideal combination of ingredients promotes better and focused energy, increased recovery rate, positive impact on metabolism, and healthier lifestyles for individuals with different workout routines, etc.

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Serious Rest Gummies

Receptra Naturals

  • Sizes – 30 gummies
  • Dosage – 25mg/dose
  • Flavor – Strawberry
  • Recommended Use – Oral consumption of 1 gummy (chew entirely before swallowing) 45 minutes before the desired time to sleep. The consumer may take one additional gummy when experiencing any difficulty or discomfort to sleep.
  • 30-Day Satisfaction Guarantee

A good night’s sleep is essential to be able to achieve a healthy lifestyle and ideal productivity. However, many factors may affect the quality of your sleep, which is why it is essential to utilize your time carefully and devote enough time to sleep.

The careful formulation of the  Receptra Serious Rest CBD + CBN gummies enhances your sleep, so you can wake up fresh to conquer the next day. These Mountain Strawberry flavored CBD gummies are perfect to help you fall asleep effortlessly, and make your bedtime as relaxing as it should be.

The soft and chewy texture of these gummies makes them even more enjoyable. Moreover, they consist of 25mg CBD in every gummy with the additional benefits of CBN which help promote ideal sleep for the consumer. CBN is a naturally occurring cannabinoid that has been proven beneficial and the perfect complementary cannabinoid for CBD.

With no melatonin in the gummies, Receptra Naturals makes sure to allow the cannabinoids to do all the work. Furthermore, these vegan-friendly CBD gummies consist of pectin instead of gelatin, which allows consumers to enjoy these gummies and achieve their well-deserved rest, without needing to compromise on their lifestyle. These gummies will help achieve your active and healthier lifestyle, with the crucial rest you deserve and can rely on.

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CBD Pain Relief Boxed Set

Receptra Naturals

  • Contents –  Serious Relief 33 + turmeric tincture, Serious Relief Targeted Topical Stick
  • 30-Day Satisfaction Guarantee

Receptra Naturals brings together the powerful combination of their 2 best selling products to help promote better recovery with minimized discomfort. Moreover, the limited edition packaging, makes it the ideal gift for our active and diligent friend or loved one, on any special occasion.

Serious Relief 33 + Turmeric tincture (1oz)

The ideal blend of the perfect ingredients – turmeric, MCT oil, omega 3 and omega 6 fatty acids, avocado oil, help the consumer achieve a better metabolism, more focused energy, and increased recovery rate. The CBD hemp tincture also helps overcome the physical discomfort in many individuals, so they can conquer their preferred lifestyles.

Serious Relief Targeted Topical Stick (2oz)

This topical stick helps to conveniently target the acute pains in individuals, usually caused due to injury or strenuous exercise, for the ideal topical relief. 2 of the organic ingredients are arnica and jojoba that aid in the lessening of inflammation and swelling. Moreover, the natural scent of this CBD stick is the perfect blend of ylang-ylang, jasmine, and camphor. This helps aid in effective muscle and joints recovery, allowing pores to open for deeper delivery.

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Total Wellness CBD Boxed Set

Receptra Naturals

  • Contents –  Serious Rest + Chamomile tincture (0.5 oz), Seriously Relax + Lavender tincture (0.5 oz), Serious Relief 33 + Turmeric tincture (0.5 oz)
  • 30-Day Satisfaction Guarantee

Acknowledging your body’s needs is essential for total wellness. A calmer mind despite the stress, better sleep, can significantly promote freshness, ideal productivity, and optimal relief. If this is what you need, then Receptra’s Total Wellness CBD Set is the perfect package you’ve been looking for.

The 3 tinctures in this set enhance sleep, relaxation, and relief from the daily added stress in life. The sleek limited packaging makes it the ideal gift for a loved one, on a special occasion, or maybe when they need to obtain the perfect balance and optimize wellness.

Serious Rest + Chamomile tincture (0.5 oz)

This tincture consists of all organic ingredients, including linalool, MCT oil, hints of valerian root, and desirable flavors such as chamomile, peppermint, and vanilla. These ingredients are ideal when you want something to de-stress your body and mind, and to achieve perfect sleep, thus enhancing productivity.

Seriously Relax + Lavender tincture (0.5 oz)

This tincture is created with the ideal blend of organic ingredients that help achieve the perfect balance for the mind and body. The organic ingredients – lavender, MCT oil, passionflower, limonene, and flavors of ginger of lime, promote calmness and focus that help keeps up and go on with life’s daily activities.

Serious Relief 33 + Turmeric tincture (0.5 oz)

This tincture focuses on faster recovery and relief from all sorts of physical pain and discomfort, usually caused due to injury or strenuous exercise. The organic ingredients – omega 3 and omega 6 fatty acids, MCT oil, avocado oil, and turmeric, help promote better energy and metabolism, which also enhance the recovery rate,

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Serious Relief + Arnica Targeted Topical

Receptra Naturals

  • Dosage – 400mg CB hemp extract/jar
  • Recommended Use – On dry, clean skin, gently massage daily or whenever needed. Focus massaging on joint and muscle areas for best and faster results. Apply to dry areas, wrinkles, bruises, and blemishes of the skin. External use only.
  • 30-Day Satisfaction Guarantee

Perfect for the winters, Receptra introduces the perfect formula for whenever you are snowboarding, skiing, snowshoeing, or just enjoying another day in the snow. Winter sports tend to impact your body, for which Receptra brought back their highest-ranked limited edition Serious Relief Targeted Topical formula.

Their containers, cleverly inspired by winter sports, allow you to enjoy all your outdoor adventures, while conveniently using your topical CBD for snowboarding, skiing, and whatever else you may be enjoying in the snow.

This topical cream focuses on the irritated areas of your body with the perfect blend of organic ingredients. They help enhance faster recovery and provide relief from physical pain, after one of the harsh days on the slopes.

With the addition of jojoba and arnica, they help lessen inflammation and swelling. Moreover, it is also naturally scented with ylang-ylang, jasmine, and camphor, which help enhance effective recovery for joints and muscles, and open pores for deeper delivery.  This helps in avoiding icy thrills and tough spills.

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Whether it’s a long day after work, difficulty sleeping, physical pain or discomfort, etc, Receptra Naturals has the perfect CBD products for you. Furthermore, the 100% organic ingredients add to the reliability and effectiveness of the products, increasing the trust between the brand and the consumers. In order to avail the veteran offer, please apply here!

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General News

Pfizer COVID-19 Vaccine Provides 90% Protection: A Potential End to the Pandemic

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Pfizer

Researchers are constantly trying to invent a COVID-19 vaccine to end and control this global crisis. While many have declared expected release dates, an interim analysis has reported that a candidate from Pfizer/BioNTech showed 90% effectiveness in the protection of individuals from the COVID-19. The vaccine showed much more hope than researchers had expected in view of the companies’ analysis. Moreover, it also shows us the potential end of a pandemic which caused a global lockdown and economic shutdown.

An interim analysis provided data where the trial is to continue until the end of this year. Regulators are awaiting the vaccine and will soon begin the processing of the emergency license application promptly. Oxford University’s professor of medicine, John Bell, also a part of the research with the Oxford vaccine, praised the Pfizer team’s level of efficacy. Bell hopes for normalcy to return and prevail as he tells BBC confidently.

The manufacturing process has already begun. According to a tweet by The Hill, Pfizer CEO Alert Bourla reveals the expected global supply.

Accessibility

The joint committee in the UK, on immunization and vaccination, made some recommendations. Considering the success of the vaccines for senior citizens, the first recommended dose should be given to residents and home workers. The following recipients should be any citizen over the age of 80, and social care and health care workers. After that, the recipients will be in decreasing order of age.

The news, however, was a bit late to aid Donald Trump in the recent US elections. Although, Mike Pence, vice president, attempted to claim the Operation Warp Speed programme of their administration which aided the development of the vaccine. Ultimately, Pfizer denied the offer.

Senior Vice-president and the head of the research and development of vaccine at Pfizer denied all claims in an interview. Kathrin Jansen denied receiving any money from anyone, including the US government.

Safety

Currently, no such safety concerns regarding the vaccine stand out. Both companies have reported no severe side-effects. Moreover, the incredibly high percentage of protection, makes the vaccine even more compelling. Furthermore, regulators had previously stated the approval of a vaccine with a 50% rate.

Chairman rejoices the accomplishment and explains the primary set of results achieved from the 3rd phase of their trial. The results provide evidence regarding the ability of the vaccine to provide maximum protection against the deadly virus. With the increasing infection rates, economic shutdown,  and nearing collapse of the healthcare industry, it is a critical achievement.

Despite the evident excitement, many researchers are still trying to stay grounded and are waiting for the final data. However, these results will be ready after the ongoing trial has reached its completion. Over 43,000 individuals have involved in the phase 3 trials. Volunteers were given either the

  • placebo alternative like meningitis vaccine or
  • the vaccine, administered in 2 shots with a period of 3 weeks

The doctors were also unaware of the specific recipients of the placebo alternatives, to increase the reliability of the results.

It is a global achievement. As several countries rejoice, many have placed their orders for the Pfizer/BoNTech vaccine. The UK has secured 40m doses which will be able to treat 20 million citizens (the required dosage is 2 shots). Meanwhile, the EU bought 200m doses for distribution. Furthermore, the companies have also signed a $1.95bn contract with the US government, to safely deliver 100m vaccine doses at the beginning of 2021. Here’s to hoping that this global pandemic finally ends at the end of 2020.

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Cannabis

OCD – Can Cannabis Help?

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Cannabis is being used to treat OCD for due to its therapeutic properties.

For the past many years experts have tried to manage OCD with medications, psychotherapy, or a combination of both. Recently however, there is an increase in the number of researchers that are studying the impact of cannabis in soothing some symptoms related to OCD.

According to the statistics of ADAA, OCD impacts about 2.2 million adults in the US population. Equally common among men and women, this condition has an average onset age of 19 years. However, about 25% of cases are also diagnosed in children up to 14 year old.

Before we can cross-examine the effectiveness of cannabis for treating symptoms of OCD, it is important to understand the dynamics of the condition first.

Here is what’s it like to have OCD:

What is OCD?

OCD or Obsessive Compulsive Disorder is a form of anxiety that causes extreme fixations and temptations in people. It results in compulsions that are powerful enough to interfere with the daily lives of its victims.

The impulses created by OCD are often beyond rational reasoning or understanding on the surface for those around the patients. But for the patients the impulses can be irresistibly compelling, making them helpless at the hands of their intrusive thoughts.

This forces them to repeat their actions unwillingly. Most of the time, these actions are triggered by confusions, insecurities or fears. Excessive double checking of things, spending a lot of time washing and cleaning or continually rearranging things are all some examples of OCD behaviors.

The severity of the symptoms depends largely upon the stage that patients currently stand at. Milder symptoms often go unnoticed by family or friends. In contrast, severe symptoms can negatively impact social relationships and result in a lot of mental stress for the patients.

How Cannabis helps to deal with OCD

Cannabis and its derivatives are gaining renewed spotlight in the medical world for their therapeutic properties. With hemp becoming legal throughout the United States, more and more studies are now  dedicated to gauge its effectiveness for a number of ailments. Although still restricted, the same is true for its sanctioned counterpart marijuana in states where it is considered legal.

When it comes to judging its effectiveness for OCD, it is important to note that most researchers agree on the fact that OCD is caused by inflammations in certain parts of the brain.

According to Dr. Jeffery Meyer head of the Neurochemical Imaging Program, “Our research showed a strong relationship between brain inflammation and OCD, particularly in the parts of the brain known to function differently in OCD. This finding represents one of the biggest breakthroughs in understanding the biology of OCD, and may lead to the development of new treatments,”

Role of Cannabis in soothing brain inflammation

CBD, a derivative of cannabis has been shown to work for reducing inflammation, oxygen buildup and brain cell decline in patients suffering from Alzheimer’s. This ability of the drug has helped it combat diseases like Alzheimer’s, dementia and Parkinson’s.

Role of Cannabis in breaking impulsive thoughts

Studies conducted by the University of Washington have found that cannabis may have a positive impact on OCD patients. They researchers studied around 87 patients and tracked the impact on their OCD symptoms after about 1,810 cannabis use sessions.
At the end of the study it was found that about 60% patients reported a reduction in their compulsions. In additions, about 49% experienced a reduction in their intrusions. Moreover, almost 52% were able to control their anxiety after inhaling cannabis.

Role of Cannabis in breaking anxiety cycles

The endocannabinoid system (ECS) of the body plays a very vital role in regulating all other physiological processes and maintaining a state of homeostasis in the body. Cannabinoids (endocannabinoids) produced by the body are very similar in chemical structure to the cannabinoids produced by the cannabis plant (phytocannabinoids).

This allows the components of cannabis to react efficiently with the ECS and regulate any disturbances their in.

People with OCD experience continual anxiety that puts their bodies under huge stress. This long-term exposure to stress leads to other physiological problems like depression, weight gain and panic attacks.

When cannabis derivatives like CBD and THC enter the body, the ECS starts increasing the levels of serotonin. Serotonin is a feel good hormone that relaxes the mind and triggers feelings of pleasure in users. In addition to this, it controls the expression of cortisol – a hormone that primarily increases stress.

It is important to note here that while higher concentrations of CBD do not increase anxiety, higher THC levels may be counter-productive. This is because THC is a psychoactive component of cannabis that causes addiction and dependence. Heavy doses of THC can

 

 

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