Unlike methamphetamine, cannabis doesn’t destroy brain cells. Cannabis doesn’t cause the withering away of connections between these cells either, like alcohol. However, a diminished effect better known as “tolerance” can be caused by repetitive cannabis consumption.
Cannabinoid type I (CB1) receptors in the brains, decrease with continued cannabis use and could be the explanation of the reason for a consumer’s tolerance to THC. This implies that a consumer may need to consume more of the high-inducing THC to get the desired effects until the continued use of overtime makes it impossible to achieve the high at all.
However, the brain is an impressive organ and can recover incredibly quickly, generally within weeks, if the use of cannabis is stopped.
CB1 receptors are activated by THC to make a consumer high, which is essentially an abnormal increase in the activity of CB1 receptors. The activity returns to normal, once the THC is gone.
However, continued exposure of THC to the brain over a couple of days of weeks, causes the brain to take action and minimize the increase in CB1 receptor activity.
Development of THC tolerance
Repeated activation of CB1 receptors causes THC tolerance because they initiate events inside the brain cells that lead to desensitization – weakening of the response to THC, followed by internalization – the removal of CB1 receptors from the surface of the cell. Desensitized receptors still hold availability for the binding of THC, however having lower impact once they bind. On the contrary, internalized receptors are no longer available for binding to THC.
These processes are initiated by the activation of CB1 receptors by THC. With the frequent activation of CB1 receptors, there is less association with the components that carry out the receptor effects.
Components within the cell that tag the receptor with a phosphate group, detect CB1 receptors, and signals to additional components within the cells, for the removal of the receptor from the cell’s surface. Hence, continued consumption of THC will eventually leave less of an effect on brain functioning due to the decreased number of receptors for it to act on.
The time needed for a consumer to develop tolerance to THC (which reflects CB1 receptor internalization) depends on the dose and the frequency of consumption, use history, and DNA. While there is a huge variance of these factors among individuals, the best understanding of the time course for the development of tolerance, comes from mice.
Injections of THC at 10mg/kg were given to mice, twice daily, where the mice developed tolerance to THC’s pain-relieving and sedative effects after a course of 36 hours. A suggestion of susceptibility of tolerance of different brain regions or brains cell was implied by the results showing stronger tolerance to THC’s sedative effects in comparison to its pain-relieving effects.
The THC injections were stopped after a week of THC exposure, where the behavior normalized in less than 2 weeks, with the quicker recovery of the tolerance to THC’s sedative effect compares to its effect in pain. Hence, more resilience and faster recovery are shown by brain mechanisms that promote quicker tolerance, from a period of abstinence.
The disappearance of tolerance to THC with abstinence
While recovery can be notably difficult to measure, changes in behavior, brain function, and brain chemical receptor levels can be observed as a proxy. A study conducted on daily cannabis users, concluded that consumers, compared to non-consumers, had reduced CB1 receptors, which however were increased to the normal limit in 2 weeks of abstinence. However, additional studies suggested that withdrawal can be more intense when there are fewer CB1 receptors available for binding, concluding that the internalization of CB1 receptors is indeed tolerance.
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Good news for Sciatica patients: CBD oil relieves the pain
The recent studies on CBD oil have unfolded its utility in various fields of medicine. Researches on the effects of CBD oil on sciatica patients show that they can prove to be very useful in its treatment. The results have shown that the oil can work wonders to alleviate the Sciatica pain.
What is Sciatica?
Sciatica is a severe pain caused by disruption in the sciatica nerve. Anything that disturbs the nerve results in extreme and sometimes, unbearable pain.
Sciatica is a nerve that starts at the lower back and extends through the hips and legs to the toes. It sends messages from the brain to the legs via spinal cord. Since, it is a long nerve, patients usually complain of the pain at the lower back, hips, legs and heels.
A compression on the Sciatica causes this severe pain. The major causes of compression are a herniated disk, bone spur on the spine or narrowing of the spine.
What is CBD oil
CBD (Cannabidiol) is a chemical compound that is derived from the Marijuana plant. It relieves the pain without causing any psychoactive or mind-altering effects. CBD oil is made by extracting CBD powder from the marijuana plant. Coconut or olive oil is mixed in it for better application.
The recent researches on CBD oil have revealed its anti-seizure, neuroprotective and pain relieving properties. Due to its wondrous effects on human body, many celebrities advocate for CBD.
Utility of CBD oil for Sciatica patients
CBD oil works by increasing the number of pain modulators that stimulate a response to the pain. Our mind has cannabinoid receptors that modulate the pathways that stimulate a response to the pain and negative emotions.
As sciatica pain arises, the CBD oil applied on the respective part works to reach the brain in order to stimulate a faster response to the pain.
While the Sciatica is a very painful condition, it is mostly treatable with medicines. However, most pain relievers have side effects that cause harm in the long run. In contrast, CBD oil works naturally to enhance the receptors with minimum side effects.
Best CBD oil to relieve Sciatica
Every person’s reaction to different types of CBD oil varies from the other. One cannot say with surety, since what works for some might not work for the others. This is primarily because every person has a different set of genetics, general health and tolerance.
Natural and organic remedies take time to show their reaction. While CBD takes some time to relieve the pain, it is undoubtedly one of the harmless ways to do so.
CBD oil works best when used with the consultation of a doctor. Before buying, one should make sure that the oil contains laboratory verified ingredients.
Who owns the Suspicious Marijuana Farm Near Middleton Home?
The Police discovered a Marijuana Farm near Kate Middleton’s family home in Buckleberry in Berkshire. A power outage led to the discovery of the illegal farming of marijuana right next to Middleton’s 18 acrea estate, on Thursday.
The Middleton Estate
Kate Middleton’s parents, Carole and Michael Middleton, own a £4.7 million Grade II Manor house in Buckleberry in Berkshire. The purchased this property back in 2012 after moving from their £1.5 million house in the same village of Berkshire. The 18-acre estate consists of 7 bedrooms and 5 reception rooms. Carole and Michael moved here due to the better privacy and security this house offered.
The Middleton Family House holds great importance for the Duke and Duchess of Cambridge. The Duke and Duchess have spent a lot of fun moments at ‘The Manor’. All the sweet memories make The Manor a strong fort to hold.
Discovery of the Marijuana Farm
Upon calling, people from the electricity board came to solve the electricity power situation. The workers from the electricity board discovered the Marijuana Farm on the Wednesday night. They immediately brought this to the attention of the police. The police raided the area on Thursday and found an empty Cannabis factory.
A witness reported that about 6 vans collected the content inside the potential cannabis factory. The police has taken all the evidence for further investigation. The Police is investigating this case under the top priority badge. They have found some evidence that the empty and abandoned factory was previously being used as a safe space to make drugs from cannabis.
Until now, no arrests have been made and people are clueless about the owner of the factory. The police has asked the public to contact police if they have any information regarding the suspicious factory hidden in the barns. The investigating officer told the media that they are still carrying out an investigation. They are confident that they will soon get to the bottom of this matter.
As suspicious as it might sound, there is no confirmation to it. Kate Middleton is the Queen of Grace and her family is an epitome of class. The rumors about the Cannabis Factory being owned by the Middletons are circulating however, it seems nothing but a rumor. Royal family has always been subjected to such fake news every now and then. Previously rumors about Kate’s fourth pregnancy were also in the air and Kate having marital issues with Prince William also surfaced.
While the Police and CID are working hand in hand to solve the mystery of the Cannabis factory and marijuana farm right next to the Middleton Family House, people are looking forward to get their hands on the latest gossip.
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