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Canadian Prime Minister Approves First Clinical Trial for Potential COVID-19 Vaccine

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In the existing ongoing research for potential vaccines worldwide, the first Canadian clinical trial has been officially approved by the Canadian Prime Minister, Justin Trudeau, for a potential COVID-1 vaccine. According to the reports by Xinhua news agency, the Canadian Prime Minister, on Sunday at his press conference in Ottawa, had reportedly said that Health Canada had given the green light to the Canadian Center for Vaccinology at Dalhousie University, to begin the clinical trials of the vaccine candidate.

According to Trudeau, production, and distribution in homes, could begin if these vaccine trials prove to be successful. Trudeau added that while it may take time for research and development as it must be done right, this news is incredibly encouraging. 

Trudeau has reported that the National Research Council of Canada will be working with the manufacturers of the potential vaccine so that if the trials prove to be successful, it would lead to the domestic manufacture. 

There were at least 75,770 cases of COVID-19 that were confirmed as of Saturday afternoon, along with 5,677 deaths in the country. 33 clinical trials have been reportedly authorized by Health Canada, for supportive care or treatments for the COVID-19 up to date. The announcement of the vaccine trial was made on Saturday, and further marks the first Canadian endeavor at finding a vaccine for the disease, that was approved. 

The announcement was made several days after the announcement by the health agency, of the first authorized us COVID-19 serological tests, or antibody tests, in Canada.

A collaboration was announced on May 12, of the National Research Council of Canada with CanSino Biologics Inc. (CanSinoBIO), for the further advancement of bioprocessing and clinical development in Canada of a candidate vaccine against COVID-19.

The vaccine candidate is referred to as Ad5-nCoV and is the recipient of the Chinese regulatory approval earlier this year, which in turn allowed the CanSino Biologics to move ahead with the human clinical trials in China. 

So far, it is one of only a handful of vaccine candidates in the world against COVID-19, that have been approved for the initial safety test for humans, and was also the first vaccine that had begun the Phase II human clinical trials. 

CanSino Biologics and the National Research Council for Canada have brought their respective technologies together, along with their expertise, to come together to fight COVID-19. Furthermore, they are also aiming to pave the way to conduct more clinical trials in Canada in the future, with an expecting collaboration with the Canadian Immunization Research Network at the Canadian Center or Vaccinology. 

Moreover, the vaccine is also subject to approval by Health Canada. Furthermore, a Clinical Trial Application is also in the process of being filed by CanSinoBIO. However, much more needs to be done before a vaccine can be made available. According to the Health Canada website, there is more regulatory oversight needed for biologic drugs, in comparison to chemical drugs.

The vaccine, or as referred to the Ad5-CoV, was developed by using technology from both countries, China and Canada. Furthermore, the vaccine was also co-developed by the Beijing Institute of Biotechnology (BIB) and CanSino Biologics Inc. with the use of replication-defective adenovirus type 5 vector, which was genetically engineered. This will be able to express the SARS-CoV-2 spike protein and was grown using the living cells that were designed and developed at the National Research Council of Canada.

A billion-dollar investment in medical research, was made by the federal government, to fight COVID-19, with the inclusion of $23 million for the support of pre-clinical testing and the clinical trials of a potential vaccine in Canada, along with the %29 million for the production of vaccines. 

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General News

Tear Gas on Protestors is increasing Coronavirus Cases

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Recent protests in the Unites States have led to a lot of unrest in the country. The police are using tear gas as a means to keep the crowds under control. However, experts have said that the use is only increasing the number of coronavirus cases.

Coronavirus has been actively spreading for the past 8 months. The United States saw one of the worst waves of the virus in the past 30 days. It affected thousands of people, killing hundreds in the span of just a few days. The governments have put majority of the nations in lockdown to control the transmission. However, with every passing day, the cases seem to be increasing.

The recent George Floyd incident was an act of white supremacy. This significantly worsened the situation. Hundreds of protestors came out on the streets to fight for the colored community. The hashtag “#BlacklivesMatter” was trending and numerous people across the globe rose for their support.

Via Stars and Stripes

 

Also read: New York passes a bill to legalize Marijuana

To keep the masses in control, police has been using tear gas and pepper spray. There is a range of side effects of using these compounds. It causes extreme cough and sneezing. Further, it also irritates the eyes, causing temporary blindness.

Side effects of Tear Gas

While, the protests were bad enough for the coronavirus, the use of tear gas has added more risk of contracting the disease. Since, the virus is transmittable through air, the protests alone have caused a drastic increase in the number of new cases per day. Additionally, due to excessive cough caused by the sprays, infectious droplets are released into the air. These are then inhaled by the neighboring protestors, causing an increase in the number of effected people.

Dr. Peter Chin Hong brought this issue to the public. He is a professor of medicine and an infectious disease specialist at University of California in San Francisco.  He said that the use of these harmful sprays cause people to take off their protective masks. It also makes them rub their face and eyes to counter the extreme irritation. Further, the compounds in the sprays also cause inflammation of the lung tissues, making the people more susceptible to infection.

Dr. Hong and more than 1000 other health experts have signed a petition to stop the use of these sprays. Hong said, “It’s easier to spread because people don’t know they’re sick.” According to statistics by the U.S. Centers for Disease Control and Prevention, around 20 to 50 percent of the coronavirus patients are asymptomatic.

Therefore, it is extremely important that the government takes immediate measures to control the further spread of the disease. Currently, the officials have advised the public to wear face masks, use sanitizers and stay at least 6 feet away from each other.

Also read: Good news for Sciatica patients: CBD oil relieves the pain

About the George Floyd Incident

George Floyd was a 46 year old, black man who died in police’s custody in Minnesota. Derek Chaivin, a white police officer was kneeling on Mr. Floyd’s neck as he gasped for air. Floyd was constantly pleading to let him go since he could not breath. He was also unarmed and was constantly complaining of chest pains. Due to lack of empathy from the police officer, Floyd passed away on the spot.

 

via Vietnam Times

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Cannabis

Who owns the Suspicious Marijuana Farm Near Middleton Home?

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The Police discovered a Marijuana Farm near Kate Middleton’s family home in Buckleberry in Berkshire. A power outage led to the discovery of the illegal farming of marijuana right next to Middleton’s 18 acrea estate, on Thursday.

The Middleton Estate

Kate Middleton’s parents, Carole and Michael Middleton, own a £4.7 million Grade II Manor house in Buckleberry in Berkshire. The purchased this property back in 2012 after moving from their £1.5 million house in the same village of Berkshire. The 18-acre estate consists of 7 bedrooms and 5 reception rooms. Carole and Michael moved here due to the better privacy and security this house offered.

Image Credits: Zimbio.com

The Middleton Family House holds great importance for the Duke and Duchess of Cambridge. The Duke and Duchess have spent a lot of fun moments at ‘The Manor’. All the sweet memories make The Manor a strong fort to hold.

Image Credits: express.co.uk

Discovery of the Marijuana Farm

Upon calling, people from the electricity board came to solve the electricity power situation. The workers from the electricity board discovered the Marijuana Farm on the Wednesday night. They immediately brought this to the attention of the police. The police raided the area on Thursday and found an empty Cannabis factory.

 Also read: House Fire exposes illegal marijuana operation

A witness reported that about 6 vans collected the content inside the potential cannabis factory. The police has taken all the evidence for further investigation. The Police is investigating this case under the top priority badge. They have found some evidence that the empty and abandoned factory was previously being used as a safe space to make drugs from cannabis.

Until now, no arrests have been made and people are clueless about the owner of the factory. The police has asked the public to contact police if they have any information regarding the suspicious factory hidden in the barns. The investigating officer told the media that they are still carrying out an investigation. They are confident that they will soon get to the bottom of this matter.

Also read: WHO – New Study Suggests Face Mask Could Reduces the Risk of COVID-19 by 85%

Baseless Rumors

As suspicious as it might sound, there is no confirmation to it. Kate Middleton is the Queen of Grace and her family is an epitome of class. The rumors about the Cannabis Factory being owned by the Middletons are circulating however, it seems nothing but a rumor. Royal family has always been subjected to such fake news every now and then. Previously rumors about Kate’s fourth pregnancy were also in the air and Kate having marital issues with Prince William also surfaced.

While the Police and CID are working hand in hand to solve the mystery of the Cannabis factory and marijuana farm right next to the Middleton Family House, people are looking forward to get their hands on the latest gossip.

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WHO – New Study Suggests Face Masks Could Reduce Risk of COVID-19 by 85%

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The World Health Organization (WHO) recently approved a new review. The review emphasizes the importance of social distancing, face masks, and eye protection to decrease the spread of COVID-19. However, this applied to both health care settings and the general public. Furthermore, the review also mentioned that a safe distance of at least 3 feet (1 meter) between individuals would decrease the chances of infection by 82%. Moreover, the review has encourages a more effective distance of 6 feet (2m).

Why are face masks important?

Face Masks Covid-19

The New York Times

Face masks and cloth face coverings can potentially protect the general public and health care workers from COVID-19. However, the researchers emphasized that N-95 masks are more effective than other masks, especially in the health care industry. Due to the method of transmission, individuals are focusing on protecting their nose and mouth. However, the authors stated that eye protection might be just as beneficial as masks, and provide further protection.

However, the authors have acknowledged the limitations of the evidence regarding face masks and eye protection. Furthermore, none of the above ways are guaranteed 100% protection from COVID-19. Lead author and clinician-scientist in the Department of Health Research Methods, Evidence and Impact, and Department of Medicine at McMaster University Ontario, Dr. Derek Chu, had given a statement. He explained that while all measures were essential, none excluded the possibility of infection completely. He added that consequently, hand hygiene is essential to further reduce the risk of infection.

The review

A new review was published in the journal, The Lancet, on June 1. Chu and his team examined existing research on COVID-19 ad relevant conditions SARS and MERS. In totality, the researchers examined 7 studied on COVID-19, 26 on SARS, and 11 on MERS. This summed up to 44 pieces of research conducted on over 25,000 participants in 16 different nations.

The studies focused on the impact of social distancing, face masks, and eye protection on the spread of COVID-19. The researchers focused on each of them and their degree of protection separately. However, the examination of the impact of the span of potential exposure on the prospect of infection was unsuccessful.

With social distancing and quarantine, however, the risks of infection were decreased. The risks were reduced to 3% with a distance of 3 feet, and to 13% with a distance of fewer than 3 feet. Furthermore, the risk of infection decreased further with added distance.

Risk of transmission

The risk of transmission decreased with added distances and further safety protocols, such as

  • With a face mask – 3%
  • Without a face mask – 17%
  • With eye protection – 6%
  • Without eye protection – 16%
  • Social distancing of up to 3 feet – 3%
  • Social distancing of fewer than 3 feet – 13%

Every extra 3 feet of social distancing reduced the risk by half.

The study’s senior author, and a professor at McMaster University, Holger Schünemann, gave a statement. The author explained how their findings are the first to study direct knowledge of COVID-19, SARS, and MERS. Consequently, this resulted in the best obtainable proof of the optimal use of these safety measures in order to flatten the curve.

In terms of protection, further research in the health care industry has concluded a 96% effectiveness in N95 respirators. Meanwhile, other masks with the inclusion of surgical masks showed 77% efficiency.

However, the review had made its room for error and improvement. No randomized control trials were included in the review. Instead, the review focused on observational studies. In such studies, researchers assign no treatment to participants and merely observe them, to conclude results. However, there is a need for randomized controlled trials, particularly on the impact of face masks on the rate of transmission. Thankfully, the authors have stated that two trials are ongoing in Denmark and Canada.

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