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Can Cannabis-based Drug Treat Brain Tumors? UK Trials Designed To Discover More

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Marijuana cannabis effects on brain

Brain research studies have occurred previously, but the UK-based trial will analyze cannabis-based drug efficacy in treating brain tumors. Thus, this clinical project is different, and its findings can be life-changing for many patients. 

 

The University of Birmingham is planning to coordinate a UK trial. The aim of organizing this trial is to analyze the efficacy of Sativex in treating the most aggressive brain tumors. Sativex is a marijuana-based drug.

ALSO READ: Is Tobacco Industry Shifting To Cannabis

Within the United Kingdom, the NHS has allowed only limited medical marijuana products. Doing so controls the use of medical pot products. It also makes it difficult for all patients to get access to pot-based treatment programs. 

 

Brian tumors are very aggressive sometimes and may remain silent for multiple years. Treatment of such tumors is complex. But there are possibilities of treating them with the marijuana-based drug. The UK trial will help to determine efficacy, safety, and chances of treating neurological tumors. 

 

The UK Trial On Cannabis-Based Drug

 

The Brain Tumor Charity is funding the new phase II trial. The trial involving cannabis-based drugs is going to launch at 15 NHS hospitals. The phase I study in 27 patients has shown promising results, and researchers are hopeful about effectiveness in the new phase II trial. 

 

Glioblastoma is an aggressive brain tumor that has an average survival of fewer than ten months. The treatment is not much effective, and its progression occurs at a faster rate. Due to multiple reasons, patients suffering from glioblastoma are unable to continue living a healthy life. 

 

In the UK trial, patients will receive Sativex together with their chemotherapy. The trial will determine whether or not the cannabis-based drug Sativex increases the survival rate of patients with brain tumors. 

 

Phase I Cannabis Involving UK Trial 

 

Sativex is a marijuana-based drug, it is an oral spray that contains cannabinoids THC and CBD. This drug has shown promising results in phase I trial and improves the condition of people fighting with glioblastoma.

ALSO READ: Explosion Caused By Invercargill Couple During Cannabis Oil Production

The cannabis-based drug has a good efficacy profile in treating patients with multiple sclerosis. During the phase one trial, Sativex was effective when given chemotherapy to patients suffering from a brain tumor. 

 

During the phase, I study the number of patients on Sativex who were observed to live longer than those patients, that were on placebo. However, sufficient data from the phase I study, to show survival impact was not gathered. 

 

Phase II UK Trial To Determine Pot Role In Treating Brain Tumors

 

The phase II trial is called ARISTOCRAT. This trial will continue to research and investigate by observing patients receiving cannabis-based medicine for three years. A placebo group will also be under observation during this time.

 

Professor Susan Short is leading the phase II trial at the University of Leeds. The Cancer Research UK Clinical Trials Unit at the University of Birmingham also co-ordinate the study.

More than 230 patients with brain tumors are to gather from all across the UK nations to conduct the trial. The procedure will begin in early 2022, and the process of funds collection is ongoing.

 

Due to the pandemic, the income of the Brain Tumour Charity decreases by 25 percent last year. As a result, they had to discontinue their research grant funding program. Today the organization launched an appeal to raise £450,000 to open the trial involving the cannabis-based drug.

 

Glioblastomas are one of the most common and aggressive forms of brain cancer. Each year in England alone, about 2200 people are diagnosed with it, with the lowest survival rate. 

 

Moreover, glioblastomas are fast-growing, highly diffusive, have poor boundaries, and extend to multiple parts of the brain. After intensive treatments, including surgery, these brain tumors develop again and again in different areas.

 

Cannabis-based drug effectiveness can give hope and relief in treating and prolonging the life of patients with these aggressive tumors. It is essential to conduct the trial as soon as possible. 

The author is a graduate of dental surgery from the Dow University Health Sciences, Karachi. She has an academic background in content writing as well as English literature, giving her an edge in the field. Adeena is always curious about physical and mental health. She is always passionate about research and delivering high-quality reliable content to users.

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No More Firing Or Barring of Workers Or Applicants Over Cannabis Screening, Says Amazon

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No More Firing Or Barring of Workers Or Applicants Over Cannabis Screening, Says Amazon

Amazon has been in favor of legalizing and decriminalizing cannabis in all states. The company favors federally altering reforms to make new legislation for legalization and decriminalization of marijuana. It also supports altering employer-employee policy with respect to new legalization rules. 

 

Amazon reestablished its employment eligibility criteria for previous workers or job applicants. Previously, the company used to fire employees with positive cannabis screening results. The same used to happen with job applicants, they were considered ineligible to apply for any job. 

 

Moreover, in June 2021, Amazon changed its policy and ended pre-employment cannabis screening for many applicants for various job posts.

 

Amazon And Cannabis-Employment Policy

 

Amazon is one of the largest e-commerce platforms with millions of clients and workers. The company is planning to further relax its cannabis screening policies to support federal legalization legislation.

ALSO READ: Best CBD For Terriers Dogs

The previous cannabis employment policy contains that individuals, former workers, and applicants, that use cannabis will be fired or will not be selected for any post. However, things change over the last 18 months. Now people with a history of using marijuana and those with positive screening results can continue their jobs and office work freely irrespective of pot usage.

 

The pre-employment test and screening processing adversely affected many people, especially people of color. Minority communities are most affected. According to Beth Galetti, people of color suffer from these policies, and the team of employees and employers in Amazon consider such behavior unacceptable. The people of color had to go through inequitable treatment.

 

Changes In Employment Policy

 

In June this year, the company announced that it no longer screens its workers for cannabis. However, the company’s new employment policy requires employees and applicants for the Department of Transport to pass through a marijuana screening test. Employees such as heavy equipment operators and truck drivers have to clear marijuana screening before beginning their job and can be asked to perform screening whenever necessary.

 

Hiring cannabis consumers was a positive change in the employment policy made by Amazon. Hopefully, many other companies will follow the example and bring an alteration to society. 

 

Yet employees will go through regular tests, including tests for alcohol and other drugs. The company can ask employees to undergo a drug test after any incident. 

 

Why Allow Cannabis users To Apply And DO Jobs?

 

Amazon observed that many states are legalizing and decriminalizing marijuana. After learning the change in perspective of the public and legislators, the company also decided to relax its cannabis standards.

ALSO READ: New York Cannabis Industry And Park Strategies

According to Beth Galetti, allowing former cannabis users to apply for a job will lure more applicants in a tight labor market. It will also reduce the suffering of people of color somehow.

 

Amazon is looking for field experts and enthusiastic employees. According to Galetti, they have discovered that eliminating pre-employment testing for cannabis permits the company to expand its applicant pool. 

 

According to Bloomberg, Amazon encourages its delivery firms to advertise that they do not require cannabis screening. Also, the company is lobbying the federal government to legalize pot. Amazon supports the Marijuana Opportunity Reinvestment and Expungement Act. The objective of this act is to decriminalize cannabis at the federal level. One of the aims is to expunge criminal records. According to the Act, this will bring investments to these communities. 

 

Amazon also recently endorsed a similar bill on Tuesday called the Cannabis Administration and Opportunity Act. The company is urging congress to expunge federal nonviolent marijuana crimes and legalize pot federally. 

Originally Covered On: CNBC

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Best CBD For Terriers Dogs

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Terriers are adorable, caring, and always on alert among other breeds of dogs, and CBD products can be beneficial for them. There are multiple CBD-containing items available in the market that can be helpful supplements and promote the health of your terrier.

Of the many dog breeds, terriers are unique as they are independent, courageous, first to respond to anything, potentially noisy, determined, and possibly destructive. These dogs are excellent or enthusiastic diggers. CBD gummies or oil containing cannabidiol can reduce the anxiety of terriers in an unfamiliar place.

Having a terrier is a life-changing experience for many people. Despite being small, terriers are energetic and fill the air with their warmth and love.

Terriers are usually very active and move around frequently. This characteristic makes them potentially destructive. In a stressful environment, they tend to move around more often, causing an increase in chances of household destruction. However, CBD products for reducing the anxiety of terriers can be effective in calming the dog.

9 Best CBD Oils for Terrier

You can resolve certain disease conditions and health issues by finding a suitable CBD item for your terrier. Of the many items available in the market, the following are the best CBD for terrier dogs.

  1. Honest Paws Dog Oil
  2. Innovet Dog Treats
  3. Nuleaf Naturals
  4. Joy Organics
  5. EVN CBD
  6. Charlotte’s Web
  7. Relieves
  8. Medterra
  9. CBDPet Hemp Oil Extract

 

  1. Honest Paws CBD Dog Oil – Best For Terrier with Arthritis or Seizures

Honest Paw CBD oil for terrier dogs supports and encourages long-term health in your pet. It is the best choice to improve the health condition of your canine and reduce pain from arthritis. It is also suitable for terriers with seizure issues.

You can add Honest Paw Dog CBD oil to your terrier food and make it part of your daily dietary intake. This product contains naturally occurring cannabidiol obtained from stalks, flowers, and leaves of the hemp plant.

The THC content in Honest Paws Dog Oil is less than 0.3%. Thus, its consumption causes no problem and makes it a safe supplementary item. There are two special oils: calming CBD terrier oil and mobility CBD oil. The Calming special oil contains hemp extracts in combination with chamomile to enhance relaxation and calming effects.

ALSO READ: Best CBD Oil For Cats

The mobility CBD oil contains organic full-spectrum hemp oil mix with organic turmeric. This combination of ingredients makes the product a suitable anti-inflammatory item for relieving uneasiness from daily actions.

If you want CBD oil to promote the health of your terrier by administering organic full-spectrum hemp oil, you can choose Honest Paws CBD oil for Dogs- Wellness.

Pros

  • High CBD content obtained from the hemp plant
  • Encourage positive health changes
  • Reduce pain
  • Improve sleep patterns
  • Promote homeostasis
  • Easy to administer
  • Infusible with dog treats,
  • Promote mobility by supporting joints
  • Safe and secure shipping
  • 30 days money-back guarantee
  • Auto-refill at and deliver every one month
  • Non-GMOs
  • Third-party laboratory tested
  • NASC- certified

Cons

  • Terriers may experience mouth dryness
  1. Innovet Dog Treats – Best CBD Treats

Innovet CBD dog treats are effective in relieving terriers of their pain and enhancing their defensive system. These unique dog hard chews and soft chews both contain cannabidiol and active hemp extract.

These CBD dog treats contain the same quality of cannabidiols as full-spectrum CBD oil does. Most CBD oils do not have flavoring options. Whereas dog chews have multiple flavoring options, are safe to use, and have excellent quality.

All the ingredients of Innovet dog treats are natural and efficient in improving the health of your terrier. The chews are available in perfect-medium to large-sized treats with a crunchy texture and delicious taste.

Each hard chew contains 5mg of hemp extract, and the packet contains 125mg of hemp extract. The Innovet dog treats also contain vitamins, minerals, omega fatty acids, and a combination of some other supplements to promote the health of your terrier.

These treats infused with CBD enhance the immune system of dogs. Improving the defensive system enables your terrier to protect himself from fatal diseases.

The hard dog chews contain organic hemp extract, apple juice, natural coconut oil, eggs, garbanzo bean flour, natural beef flavor, cheddar cheese, mixed tocopherols ( Vitamin E), and flaxseed oil.

Pros

  • All natural, organic full-spectrum hemp extract,
  • Non-GMO ingredients
  • Eco-friendly
  • Third-party lab certified for effectiveness, and safety
  • Gluten-free
  • Increases immune system functioning
  • Grain-free and has no preservative
  • Gluten-free
  • Comes in steak and cheddar flavoring
  • 30 days money-back guarantee

Cons

  • No sale and purchase options for pet owners at South Carolina
  • Consult veteran if your terrier is on any medication as interaction can occur
  1. Nuleaf Naturals Pet CBD

Nuleaf Naturals Pet CBD contains full-spectrum hemp supplements oil and organic hemp seed oil. It comes with a dropper for accurate and easy dosage administration.

It is suitable for terriers of all ages, especially older dogs with declining health. Nuleaf Naturals CBD full-spectrum cannabidiol oil gives positive results in improving the health of diabetic, anxious, and arthritic dogs. Each bottle of the product contains 1800mg of cannabidiol, and each droplet has 3mg of CBD that can be mixed with your terrier’s favorite food.

Pros

  • Organic full-spectrum hemp oil
  • Non-psychoactive ingredients
  • Promote balance and optimal health
  • Third-party tested
  • Quick delivery
  • Prompt effect
  • Safe to use
  • Highest quality
  • Aid in calming terriers
  • Reduce pain
  • Available in three sizes: 300mg, 600mg, 1800mg
  • Available in three packages: single bottle, pack of three, pack of six
  • Economical

Cons

  • No refilling options
  • Lack of flavor options

 

  1. Joy Organics CBD Tinctures

Joy Organics Premium CBD Tinctures for terriers is free of THC and contains organic 3.75mg cannabidiol per quarter dropper. It is made by using USA-grown hemp to obtain broad-spectrum organic phytocannabinoid-rich hemp extract. The extract is mixed with organic olive oil to make the final effective formulation.

The Joy Organics Premium CBD Tinctures are for every terrier of different ages. The tincture has a natural-flawless flavor that dogs love. You can directly pour some drops into the mouth of your pet. Most pets like the tincture when mixed with their meal.

The high-quality phytocannabinoids formulation is laboratory tested for safety. Its safety and efficacy profile suggests that it is safe to use and beneficial as it has no THC side effects. This formulation improves the quality of life of your terrier dog.

Pros

  • USA grown organic hemp
  • Broad-spectrum
  • THC free
  • High quality and standard product
  • Third lab tested
  • Cruelty free7
  • Carbon neutral shipping
  • Available on subscription sale
  • Alcohol-free
  • USDA certified organic
  • 18-month shelf-stable

Cons

  • No money-back guarantee
  1. EVN CBD Dog Chews

EVN CBD makes many products containing cannabinoids and hemp extracts. Their cannabidiol-infused products are one of the best to form a balance between mind and body, to reduce stress and anxiety. The EVN CBD dog chews are made with help of USA-grown hemp of the finest quality. There are 20 treats per pouch, and one treat contains 4mg cannabidiol in it. The treats contain 0.0 percent THC and are safe for consumption with zero risks.

EVN CBD treats for terriers improve overall health, enhances immune function, reduces stress, and calms anxious pets. It is suitable to give half a treat to a terrier under 20 pounds and eventually increase the dose to one chew. For a terrier with a weight of over 20 pounds, 1 or 2 treats per day are sufficient. If necessary, you can administer more after consulting a veterinarian.

Pros

  • Reduce pain
  • Improves overall health
  • Reduce stress
  • Gluten-free
  • Non-GMO
  • Vegan
  • Lab tested and certified
  • Zero THC
  • Available at subscribing price
  • 30 days satisfaction guarantee

Cons

  • Terrier dogs may experience drowsiness
  1. Charlotte’s Web CBD

Charlotte’s Web is one of the best full spectrums CBD oil for baby terriers as the product helps strengthening health conditions and resolve problems relating to joints. For best results, one serving two times a day is effective.

Terriers feel much calmer after eating Charlotte’s Web CBD oil. One bottle of 100ml size contains 17mg CBD per 1ml, and it is available at the subscription price. There are two sizes: 100ml, and 30ml bottles. The product is available in non-flavor and chicken flavor form.

Charlotte’s Web CBD oil contains a large variety of naturally occurring cannabidiols and hemp-derived cannabinoids. Cannabinoids and various CBD are present in combination with MCT oil that aids digestion. The formulation enhances brain function and immunity. It also improves digestive tract functionality and resolves gastrointestinal discomforts.

Pros

  • Pesticides free
  • No damage-causing chemicals in it
  • Uses USA grown hemp
  • Tested more than 20 times, safe to use
  • Non-GMO
  • Full-spectrum cannabidiol including derived and natural cannabinoids
  • Aids digestion reduces anxiety
  • Easy to administer – comes with a plastic dropper

Cons

  • Cause terriers to experience dryness of mouth

 

  1. Relievet CBD Oil

Relievet makes CBD oils for terriers from high-quality USA-grown hemp. Their products contain cannabinoids, cannabidiol, and essential supplements to boost the health condition of terriers.

The Relievet CBD oils contain antioxidants and anti-inflammatory agents that reduce inflammation, pain and prevent damage from oxidative stress.

There are four different formulations of distinctive strengths for terriers of different weights. Each formulation contains fatty and omega acids, naturally occurring CBD, naturally retained terpenes, and antioxidants.

Relievet CBD oil is available in strengths 150mg, 400mg, 800mg, and 1500mg. each bottle is of one ounce and contains 30ml of the formulation. 150mg strength is for baby terrier of weight between 1 to 15 pounds. Dogs with a weight between 16 to 40 pounds can use 400mg CBD strength.

Terriers of weight between 41 and 90 pounds can use 800mg strength. A dog with a weight of 91 pounds to 200 pounds can use a Relivet bottle with 1500mg strength.

Pros

  • Broad spectrum
  • Four different strengths
  • No THC
  • Organic, finest quality product
  • Contains Antioxidants

Cons

  • No flavor options
  1. Medterra CBD for Dogs

Medterra CBD items for dogs, including cannabidiol oils, chews, or treats, are suitable for improving joint functioning and supporting mobility. The company focuses on improving the mental and physical condition of your terrier to support healthy growth.

Medterra CBD items for terriers are free from THC and provide pure extracts of cannabidiol and cannabinoids. The product is available in pet-friendly flavorings, including chicken, beef, and unflavored.

Medterra CBD tinctures are of three variant strengths and are available in a 30ml bottle. These strengths are 150mg per 30ml, 300mg per 30ml and 750mg per 30ml.

Pros

  • Gluten-free
  • 100% pure CBD extract
  • Three strengths
  • Lab tested
  • Available in three flavors

Cons

  • Dogs may drink more water than the usual routine

 

  1. CBDPet Hemp Oil Extract

CBDPet hemp oil extract is one of the best full spectrum cannabidiol-containing oil obtained by using the process of cold press extraction. The process is used to retain the natural value and content of the hemp plant and avoid any chemical contamination. Also, organically cultivated hemp plants from Colorado are used to make the CBDPet hemp oil extract of the highest quality with help of CO2 Extraction.

ALSO READ: Best CBD For Rottweiler Dog: Treats, Oil and Soft Chews

It is suitable for terrier dogs of older age with allergies and anxiety issues as it contains supplements and multiple beneficial CBD forms that reduce anxiety.

Pros

  • Organic hemp of highest quality
  • Delivers 3.3mg per serving of premium quality
  • Provides all-natural, full-spectrum CBD types
  • Comes with an attached dropper for easy administration
  • Third-party tested
  • 90-days money-back guarantee
  • Risk-free
  • Each bottle contains 100mg of cannabidiol
  • Does not require veterinary visits
  • Easily available and legal in 50 states

Cons

  • Has no flavor options

Conclusion

The above-mentioned CBD items of various brands are some of the best products for terriers. A terrier dog is very active but under stressful conditions becomes hyperactive. Honest Paws dog oil is one of the best choices to calm an anxious terrier with arthritis and seizure issues. Innovet dog treats are one of the best treats with zero THC content making them non-psychoactive and safe for consumption. If your dog is aging, Nuleaf Naturals can be your best choice. Joy Organics tinctures and Relivet oils are one of the best broad-spectrum CBD items. If you are looking for full-spectrum CBD oil, you can consider Charolette’s Web and CBDPet Hemp Oil Extract.

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Edible Cannabis Items Might Contain Dangerous Delta-8 THC Substances

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Edible Cannabis Items Might Contain Dangerous Substances

Cannabis-infused edibles are known as edible marijuana products. There is a high possibility that these items contain Delta-8 THC which leads to increased side effects and damage to consumers’ health.

 

A health advisory committee will discover more about the subject. An official member of the federal Centers for Disease Control and Prevention is joining hands with the Food and Drug Administration to investigate the presence of delt-8 THC in cannabis-infused products.

 

There has been an increase in the demand and supply of marijuana-containing items during the coronavirus pandemic situation. Many such products contain delta-8-tetrahydrocannabinol (THC) and (cannabidiol) CBD. But insufficient labeling of items puts consumers in jeopardy. People unknowingly consume THC and CBD, leading to intoxication. 

 

Delta-8 THC In Cannabis Edibles Intoxication 

 

Intoxication disturbs body functioning, and people, after consuming edible products of pot may develop delta-8 THC toxicity. They experience lethargy, slurred speech, uncoordinated movements, and low blood pressure.

ALSO READ: Former Hudson Valley Prison Transforming Into A New Cannabis Facility

People also develop decreased psychomotor activity, increased heart rate progression to slowed heart rate, and difficulty breathing. In some conditions, some individuals experience sedation and fall into a coma. 

 

According to the advisory, the health impacts of delta-8 THC are not available, due to a lack of research. It is not well-understood whether it is as damaging as delta-9 THC or is different from it. However, it is known that delta-8 THC is a psychoactive compound capable of causing similar impairing effects as delta-9. 

 

Presence of Isomeric Compounds In Cannabis

 

Marijuana plants contain multiple isomers that exist in various parts of the plant. Some components have beneficial effects, and others have side effects. Delta-8 THC and delta-9 THC are present in the cannabis plant naturally but only in small quantities. 

 

Delta-8 THC is present with 50 percent to 75 percent of the psychoactive punch as delta-9 THC. Various isomers of THC, including delta-8, and delta-9 come from the synthetic conversion of CBD. Cannabidiol is not psychoactive, but THC is. 

 

Delta-8 THC Containing Products Increasing In Marketplaces

 

The number of delta-8 THC-containing products is increasing in the marketplaces of both hemp and marijuana both. In some areas, sales of such items occur legally by following territorial, state, or tribal laws. According to the official CDC Health Advisory, most states and territories allow full or restricted marijuana marketplaces. In these states, hemp and its derived CBD items are undergoing sales process lawfully. 

 

The advisory also says that delta-8 THC-containing cannabis products are purchasable online. Moreover, marketing of these products occurs under the names “weed light” or “diet weed”. 

 

Many marijuana marketplaces contain several delta-8 THC-containing products, but the label mentions delta-9 THC only. The THC content in these products increases. Due to inaccurate labeling, consumers of cannabis edibles with delta-8 THC experience unexpected or increased THC intoxication.

 

CDC Reports And Delta-8 THC Containing Products

 

There is a large variety of delta-8 THC-containing marijuana products in the market. Vapes, smokeable marijuana sprayed with delta-8 THC extract, tinctures, and chocolates containing THC are in abundance in the market. Delta-8 THC contains distillates, gummies, infused beverages, and many more cannabis edible items that are purchasable from marketplaces.

ALSO READ: Cannabis Industry Welcomes Black Americans, But For Many Of Them Entry Price Is Steep

According to the advisory, there is no testing procedure available to determine the presence of delta-8 THC in marijuana edibles. Testing methods are in the development process and require research and time. Moreover, testing to determine the presence of contaminants does not occur due to a lack of advanced testing procedures. These contaminants like heavy metals, solvents, insecticides, or pesticides may cause adverse reactions in consumers. 

 

The CDC report indicates an increase in delta-8 THC intoxication cases. CDC gathers information from emergency departments participating in its National Syndrome Surveillance Program. 

 

Thirty-nine percent of the patients admitted to the emergency department due to delta-8 intoxication are younger than eighteen years of age. Eighteen percent of those taken to the emergency department require hospitalization to recover from in-toxicity of delta-8 THC.

Originally covered on: foodsafetynews

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