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Is Cannabis Abuse Disorder Acquired Genetically?

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A new study suggests that there is a specific gene in the human body that has a direct link with cannabis abuse. The risk factor gene acts as a pseudoreceptor for nicotine in the brain. People having a minute quantity of the receptor are at greater risk of becoming a victim of cannabis abuse — scientists from the Danish psychiatric project conducted this study.

They found out that cannabis abuse, formally known as Cannabis Use Disorder, has a connection with a specific variant. That variant has a direct influence on the production rate of a specific nicotine receptor in the human brain. The article appears online in the journal called Nature Neuroscience.

How did the scientists extract the results?

Consumers of the type of cannabis containing THC become dependent on the substance with a ratio of 1 to 10. Ten were the total number of cannabis consumers. People have been using this drug the most frequently based on its psychoactive component present in it.

The disorder follows an association with a specific genetic component. The twin inheritance estimate is between 51 to 70 percent. Scientists studied 2387 cases and a control group of 48,985 individuals. The replication was studied among 5,501 cases. The control group here constituted of 301,041 individuals. They conclude a risk locus for the disorder on a genomic basis that replicated in the community.

What do the results interpret?

The specific gene rs56372821 is a potent expression for the trait that has an association with cannabis abuse among individuals. The combined analysis manifested that there was a noticeable decline in the cannabis use disorder that affected the cognitive functioning in individuals abusing cannabis that contained the psychoactive compound THC.

Consequently, the final results showed an in-depth physiological mechanism. It also hints details on the genomic map of the cannabis use disorder.

The specific gene influence the formation process of the certain receptor of nicotine in the human body. Moreover, Individuals having a less amount of this receptor in their bodies are at significantly greater risk of developing the disorder.

Scientists conducted the study in Denmark. It was cohort-based research to figure out the genomic map of around two thousand cannabis abusers and fifty thousand non-abusers of the substance. Furthermore, the scientists double-checked their results and studied another 5,500 cases and around three hundred thousand non-abusers.

Not only this, but the scientists in the study also analyzed the data from genetic studies that showed the genetic factors involved in the cognitive functions in cannabis users. For instance, these functions included their concentration and memory.

Extensive link of genetic variants

At that point, they found that those having dysfunctional cognitive factors also had some specific genetic variants in their bodies. Moreover, they were also at risk of developing the abuse disorder. In addition, the three factors are inter-linked with one another. Furthermore, the research is one of a kind that provides a genetic framework for better understanding of the etiology of addictive behavior among individuals.

However, there is a need to further research on the genetic differences in individuals to extract precise information out of these researches.

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Cannabis

Mayor To Cut the Ribbon on Cannabis ‘Cookies’ Inauguration

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Mayor To Cut the Ribbon on Cannabis 'Cookies' Inauguration

Michigan is seeing an increase in activities and businesses trading in marijuana. As the marijuana economy grows, Cookies is the newest store that opens its doors to Kalamazoo city. The Cookies cannabis store will be functional from Friday, Feb. 26.

The mayor for the city of Kalamazoo, David Anderson, is the chief guest for the ribbon-cutting ceremony. The store opening will be in the morning, according to the Cookies Cannabis Official press release. Also, the address for the store is 2712 Portage Street.

Medicinal Cannabis At The Curbside

The Cannabis Cookies store will not be offering curbside sales on its first day. For medicinal marijuana sales, curbside medical sales will be active from Saturday, Feb. 27, the press release further adds.

ALSO READ: Texas Med Store Starts Selling Cannabis-Infused Gummies As Medical Marijuana

Cookies is an international cannabis lifestyle brand founded by California rapper and entrepreneur, Berner.

Also, the Cookies brand is diverse and offers an entire family of offerings, including Cookies, Lemonnade, Runtz, Powerzzzup Genetics, Minntz, and Grandiflora product lines.

Expansion Plans

Cookies CEO Berner has high hopes for the Midwest. He thinks that stores like his will boost the marijuana economy and can support the economy even during slumps. Cookies has pinpointed the region as pivotal going forwards. The partnership with Gage Cannabis is also proving great for them as the demand for cannabis and medical marijuana is increasing day by day.

The expansion is driven by key partnerships and a high influx of consumers. Consumers are not only driving up demand in Kalamazoo but in the whole of Michigan. Cookies hopes to serve this rising demand as it strikes new partnerships throughout the region.

ALSO READ: Cannabis Antibiotics Can Be Solution For Treating Drug-Resistant Diseases 

The new store will be the second Cookies store in the state of Michigan. The original location where Cookies started operations last year is at 6030 East 8 Mile Road, in Detroit.
For the state of Michigan, Gage Cannabis is the go-to partner for the Cookies store. Through these key partnerships, the whole economy benefits as this will be Gage’s seventh retail point in Michigan state.
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Texas Med Store Starts Selling Cannabis-Infused Gummies As Medical Marijuana

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Marijuana Baked Products

As more and more states legalize cannabis use, dispensaries are finding new ways to morph cannabis into daily-use things. The popularity of medical marijuana is undoubtedly off the charts.  In another of such events, one of the state’s dispensaries now offers medical marijuana-infused gummies.

The Lone Star state is the second largest of all the states, falling behind Alaska. The fact that Elon Musk has set up his residence in the state has made it even more popular. Surterra Wellness, a well-known  Florida-based marijuana company, is also operating in Texas.  with a dispensary in Austin — launched its line of Surterra Wellness is bringing cannabis-infused lineup of edibles to cater to the needs of patients and cannabis consumers alike. This will provide patients with THC in a less intimidating form. The president of Surterra Wellness is positive about the impact this lineup of edibles can have.

Gummy Bears Carrying Marijuana

Mr. Ruark, the Surterra Wellness president, believes that the popularity of gummies makes them ideal to administer medicinal marijuana. Gummies are by far the most popular dosing form in medical markets across the United States. In addition to the popularity of gummies, they also contain terpenes. Terpenes provide a plethora of therapeutic properties and is an all natural extract.

ALSO READ: Cannabis Antibiotics Can Be Solution For Treating Drug-Resistant Diseases 

They also give medical marijuana users a new way of ingesting THC. The many flavors that gummy bears are available, make it a great option to use for the deliverance of medical marijuana.

Medicinal marijuana, although legal in Texas, is under extreme regulation and restrictions. Residents must opt into the Texas Compassionate Use Program that allows subscribers to use cannabis products for medicinal purposes. This programme was created in 2015 and is caters to patients of medical conditions such as epilepsy, seizures, terminal cancer, multiple sclerosis, incurable neurological disorders, autism and ALS.

Now, with the advancements in the way marijuana is covering ground, cannabis advocates in Texas are pressuring legislators to expand the program. There are expectations that the expansion will include patients suffering from PTSD.

Ruark believes that people are largely unaware of the medicinal programme in Texas. Also, he believes these gummies will change this. He thinks that his company can raise awareness about the state’s medical marijuana program.

Increasing The Cannabis Family by 2 Million

Increased reach will allow two million patients to use it who qualify for it even now but don’t use it because they don’t know about the program.

ALSO READ: International Market For Marijuana-Infused Drinks On The Rise

The president of the dispensaries wants everyone to benefit from the nature’s gift. He wants everyone to reap the benefits of cannabis. It may be of special benefit for veterans in dealing with PTSD after their return back to a normal life.

These lovely gummy treats come in a bottle that costs $60 and contains 200 milligrams of THC in total.

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Cannabis Antibiotics Can Be Solution For Treating Drug-Resistant Diseases 

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Cannabis Antibiotics

The cannabis plant contains multiple components of varying benefits, of which some constituents are psychoactive while others are non-psychoactive and have other pharmacological impacts. Because of the pharmacological benefits, researchers are working to formulate cannabis antibiotics.  

According to the research of The University of Queensland, CBD is a component present in marijuana, is non-psychoactive, and is capable of killing bacteria. It is useable in antibiotics due to its ability to kill bacteria responsible for gonorrhea, meningitis, and legionnaires. 

Moreover, according to studies, there is a possibility that drug-resistance diseases can cause more than 10 million deaths per year by 2050. The UN warns that there is an urgent need to deal with drug-resistant illnesses. Furthermore, finding solutions to the problems of drug resistance must be of utmost priority. 

ALSO READ: The Life of Marijuana Patients Made Easy By Advanced Technology

Drug resistance is growing, leading to critical problems shortly. According to neurologists, within five years, the NHS will successfully develop effective cannabis-antibiotics. Moreover, the treatment of drug-resistant diseases will be possible with the use of this marijuana containing antibiotics. 

Cannabis In Antibiotics

CBD is the cannabidiol, a major non-psychoactive and second-most prevalent component of the active ingredients of marijuana. Two institutions researched using cannabis in antibiotics. The institutions that collaborate for research are the University of Queensland and Botanix Pharmaceuticals Limited

In their research, researchers examined how the CBD of cannabis penetrates through the protective membranes of multiple bacteria. Moreover, not only does the CBD enter the bacteria, but it also kills them. 

Of the bacteria through which CBD penetrates are bacteria for meningitis, legionella, and Neisseria gonorrhea. The legionella bacteria cause legionnaire’s disease characterized by cough, shortness of breath, high fever, muscle pain, nausea, vomiting, and headache.

The researchers found that CBD was able to break down the biofilm of the bacteria. Biofilm is a slimy build-up of bacteria released by it to survive against antibiotic treatment. Moreover, the biofilm’s slimy layer is similar to a dental plaque on the surface.

What Is In The Future For Cannabis?

Cannabis-infused antibiotics may be available in the market. According to Professor Mike Barnes, pretty-soon general practitioners will start prescribing CBD pills to treat infectious diseases. Research on marijuana is progressing fast. Moreover, there are chances of formulating much better cannabis products for medicinal use. 

According to Mike Barnes, it is high time that individuals understand the medical benefits of marijuana and take advantage of the plant to its full capacity. Moreover, the marijuana plant is useable in various ways to improve the condition of patients. 

The new research led by the University of Queensland and Botanix Pharmaceutical Limited is helpful in the subject. However, further research is vital for developing much better, safer, and effective drugs containing CBD of marijuana.

More Studies Essential For A Better Future

According to Professor Mike Barnes, if CBD is placed next to bacteria in a plate, the cannabidiol will kill the bacteria right away. However, if a tablet containing CBD is on the same plate as the bacteria, the effect of CBD will be slower. 

ALSO READ: International Market For Marijuana-Infused Drinks On The Rise

The professor is confident that with further research on the subject, better medicine formulation can occur for treating drug-resistant diseases. Moreover, UK regulators can formulate something that can fight against antibiotic-resistant gonorrhea. Furthermore, the formation of antibiotics for drug-resistant gonorrhea is the utmost priority of the World Health Organization. 

Once the formulation of the cannabis-containing antibiotics is complete, the drugs will need the approval to conduct preclinical-trials and clinical trials. After completing the clinical trials and research investigations, the authorities will consider the drugs for approval after which they will be available in the market. 

Deep studies and research investigations enable the formulation of a more effective formulation. The quicker the cannabis containing antibiotics gets approval, the sooner they will be in the market for treating drug-resistant bacterial diseases. 

 

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