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Can You Get Anxiety From Too Much Cannabis?

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According to a review in 2009, regular cannabis consumers have more anxiety than people who do not consume cannabis. There is a significant number of individuals who developed symptoms aggravating anxiety before the initial symptoms of cannabis dependence.

This trail of evidence made the scientists believe that people with pre-existing anxiety use cannabis as an anxiety-relieving medicine. They oppose the idea that cannabis might be the cause behind anxiety among the users.

The using patterns of cannabis might help comprehend behavioral tendencies. However, researchers conclude that the symptoms vary from person to person.

What are the different risk factors for anxiety in cannabis users?

The risk factors for aggravating anxiety are also multidimensional as genetic susceptibility, sex of the individual, personality traits, anxiety disorder type, paranoia episodes, abstinence state, and basal anxiety measures.

The risk factors involving cannabis include the frequency, types of active ingredients consumed, dosage, and setting.

Anxiety undoubtedly evolves uniquely in every person, and the risk factors are variable at a massive scale. However, scientists have noted that chronic consumers of cannabis often note a decline in anxiety.

On the contrary, occasional users complained of having more paranoid episodes with more intensity. With the increase in THC dosage, people also experienced higher anxiety levels.

Cannabis effects on an individual scale are unpredictable for now before its use. However, a better understanding of risk factors that include both environmental and biological factors can better guide people.
The relationship between cannabis and paranoid episodes is mostly related to the brain.

What is the relation of cannabis with the amygdala in the brain?

Active ingredients of cannabis, like tetra hydra cannabidiol, bind to cannabis receptors present in the brain. Most of these receptors belong to the amygdala, part of the gray matter involved in emotional processing, stress, fear, and paranoia.

When the THC interacts with the amygdala, a modification in the neural pathways in the brain takes place. This modification can result in over-excitation of the pathways leading to high paranoia and anxiety. This situation is more in individuals who are not regular cannabis users.

Scientists are, however, not aware of the situation yet. A proper understanding of the endocannabinoid system of the human body may guide scientists to have a better idea of the situation.

In simple words, there are receptor sites present in our body that are receptive to cannabinoids. Moreover, they also include those sites that are responsive to endocannabinoids. Endocannabinoids are the naturally occurring compounds in the body, similar to cannabinoids.

If the individual is under stressful condition or is faced with trauma, these endocannabinoids in the body start to decrease. This deficiency is compensated by artificial compounds like THC that produce a relaxing effect on the brain. This is the reason why many chronic users are fans of its anti-anxiety effects.

According to science, the cannabinoids from the cannabis restock the endocannabinoids in the human body. Therefore, the overall effect is therapeutic. The connection is also related to PTSD studies, and it might have positive effects on other mood disorders.

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Health

A Novel Way to Diagnose an Early Stage Cancer

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Typically, cancer is difficult to diagnose at the initial stage. This early-stage diagnosis reduces its complications and the mortality rate linked with it. In many countries, cancer is usually diagnosed in later stages which affects the quality of life and results in greater morbidity rates and high treatment costs.  Addressing the delays in the detection of cancer and the unavailability of effective treatment is therefore critical in all the health care settings for cancer control.

Early diagnosis strategies are used to confirm the presence of disease, monitor the process of disease and plan interventions to prevent the disease from progression. These strategies help to improve the cancer outcomes by providing care and effective treatments at the initial stage.

Factors that hinder the cancer diagnosis must be identified and addressed so that it becomes easy to implement effective treatment programs at various levels including improving diagnostic and referral capacity, community engagement to address the behavior of the patient, and ensuring the timely access to high-quality treatment.

Read more- Global Alliance for Cannabis Commerce announces GACC Certified™ testing

A team of researchers led by Professor Jenny Yang from the Georgia State University Regents identified a new method for detecting cancer at the initial stage. This method used the target MRI contrast agent that binds with proteins and detects cancer. The study is published in journal Science Advances.

To detect the metastases of the liver, new biomarkers have been identified by Yang and her colleagues at Georgia State and Emory University. Currently, cancer is diagnosed in its late stages such as biopsies. At this stage treatment options become limited and it ultimately lowers the survival rates. The recent discovery discussed in this study provides a wide range of options that includes precise treatments, effective diagnosis and reduce risk for patients.

Yang said that this method is effective as it will have many applications for diagnosis and treatment of any type of cancer. This method is already used in the lab for 10 different types of cancer.

National Cancer Institute-funded this researcher project. Researchers developed an agent which can target specific receptors known as Chemokine receptor 4 (CXCR4).  In the cancerous cells, this receptor is expressed more than normal in metastasis organs such as the liver.

It would be expected that small instances of cancer can be diagnosed through CXCR4 targeted protein-based MRI contrast agent because it beats all the barriers that hinder the early diagnosis of cancer. This new methodology shows the cancerous cells on multi-color scans known as precision MRI (pMRI).

Also read- The Deadly Coronavirus Takes 250 lives in China, Thousands of Others Infected 

In MRI technology, Gadolinium is used in contrast to agents that enhance the quality of images. In her previous research analyzing calcium, Yang decided to check the interaction of the metal with proteins.  She found that the element wraps the protein around itself and takes it to the site where the image is being formed.

Still is it difficult to diagnose cancer in the early stages even though invasive biopsies. The diagnostic tests that use these contrast agents not only detect the presence of cancerous cells but can distinguish the diseases into different stages. The beauty of this test lies in its high accuracy and sensitivity.

The U.S. Food and Drug Administration used the targeted protein contrast agent in the first step of clinical trials to check its efficiency in humans. Yang hopes that these clinical trials in patients will be conducted within 18 months to two years.

Yang is an associate professor at the Center for Diagnosis and Therapeutics. She enrolled 18 foreign and 17 U.S patients in protein engineering. Recently, the National Academy of Inventors awarded her a fellowship. Also, she has started a new company ‘InLight Biosciences’ that allows her to compete for new findings and introduced her latest discoveries to the world.

This research is based on the 2019 study published in the journal Nature Communications. In this study yang and her team identified liver fibrosis for the first time by using a collagen targeted protein contrast agent.

Yang further added that this contrast agent is used for more than 30 years in different aspects and it is my biggest contribution to the scientific world and hoping for the more to come in the future.

 

 

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The Deadly Coronavirus Takes 250 lives in China, Thousands of Others Infected 

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The coronavirus is a highly contagious pneumonia-causing illness that infects the respiratory tract and responsible for several deaths in China. But now the virus spreads globally.

The current estimates tell that its death toll has crossed more than 250 people in China and many other countries are also reporting coronavirus infections. That’s the reason countries have started pulling out their residents from Chinese cities. Coronavirus has infected more People than severe acute respiratory syndrome (SARS).

The World Health Organization ( WHO)  convoked its panel to estimate whether the Coronavirus is a global emergency. The committee has advised that it may be not the right time to make an announcement. As per to latest news there is an increment in reported cases and deaths. Most of the deaths are in Hubei Province.

Indian Health Ministry states that a local student of Wuhan was observed infected with the virus when the student returned home from Wuhan. However, the health instructor of the Philippine confirmed a woman to be safe from Virus who also traveled from Wuhan.

Read more- Global Alliance for Cannabis Commerce announces GACC Certified™ testing

Some other reports find that the only 9 persons had symptoms of cough and fever from a total of 210 people, who were transferred from China to Tokyo. Europeans countries arranged flights to bring back  Europeans. The flights brought 350 Europeans and 195 Americans to their countries. All the evacuees were observed and checked. Other countries are also making efforts to get out there citizens.

The member of the World Health Organization ( WHO), Maria Van Kerkhove speaks about the condition concerning the new virus in a media talk. The airlines have discontinued their services in China and attempts continued to discover the treatment. The South Koreans protested to urge their government officials to evacuate the seven hundred south Koreans from China.

The official Xinhua News Agency reports that the Chinese authorities are trying to fulfill the basic needs of people living in hot-spot areas. Because these areas are facing shortages in daily necessities and food. It is estimated that Wuhan city f China ensures the supply of rice, cooking oil, pork, vegetables, and eggs for the next fifteen days.

The deputy director of market supervision from the National Post, Hou Yanbo requests people not to order food or any other thing from online or home delivery business other than the daily life necessities. The Chinese authorities are trying to keep people at their homes. The foreigners living in Wuhan city can become a cause of virus spread in other countries if they allowed leaving to their homelands.

The emergencies chief of WHO, Michael Ryan, finds that China has taken extraordinary measures to face an extraordinary challenge.

Read more- First Pneumonia Related Death Reported in China

The scientists have given a rough estimate of the fatality rate seems that many virus-infected cases are missed. The death rate due to virus is estimated 2 percent in Ryan as 99 percent cases of virus-infected are estimated in China. The Chinese authorities have asked all the people who traveled from or to the Wuhan city to report to health authorities. And reports show that a person can be infectious after 14 days of leaving Wuhan.

The measures taken by China in response to coronavirus are praiseworthy as many lives will be safe due to taking some measures in time. The SARS lead to 800 people deaths in the whole world due to delayed response.

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Health

New Technology to Predict Cancer Recurrence in Melanoma Patients

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The beginning of melanoma takes place when a small pigmented spot appears on the skin. By removing the lesion, a primary melanoma can be treated but it has a tendency of reoccurrence and can spread throughout the body. A new study showed that the likelihood of cancer can be predicted after the removal of the lesion.

Despite all medical advancements, the analysis of lesion his performed in the same old way. Generally, molecular diagnostic labs have many advances for the detection of other forms of cancer but for the skin lesion cancer the way of diagnosis is very simple. The diagnosis is based on the thickness of the melanoma and microscopic features.

A patient with thinner melanomas is considered to be normal and the T stage from 1 to 4 is assigned. The complete details of this study are published in Nature Cancer.

Read more- First Pneumonia Related Death Reported in China

The researchers from the Brigham and Women’s Hospital in collaboration with international colleagues showed a new technique about the reoccurrence and spread of melanomas. It leverages the sequences of DNA for predicting the possible factors involved in the reoccurrence and spread of melanomas.

Thomas Kupper who is the chairperson of the department of dermatology at the Brigham that there were no treatments available for metastatic melanoma 10 years ago. But now it is possible to treat the patients who have metastatic melanoma and these treatments can be given at the primary stage of the disease. It is important to have a clear idea about the patient’s progress report after giving the new immunotherapy treatments, so we can modify the treatment.

There are immune checkpoint inhibitors that can reinitiate the immune response through T cell against the cancer cells. These inhibitors have changed the results and options for the patients in which cancer has spread throughout the body. Immune checkpoint inhibitors can start dramatic responses such as long-term remission in the period of curing a patient.

Read more- Global Alliance for Cannabis Commerce announces GACC Certified™ testing

Kupper and colleagues wanted to know about some measurable features of T cells. These features are used to check the predictions of the reoccurrence of melanoma in the removed primary melanoma and disease-free patients. Scientists study T2, T2, and T4 primary melanoma as the T1 are rarely metastasized melanoma.

They also face difficulty in finding the sample that was enough for results because skin lesion surgeries are usually performed at private clinics and ambulatory clinics. So, the concentration of the specimen is not available in the hospitals. For resolving this issue and for sharing the resources researchers collaborated with colleagues of the Melanoma Institute of Australia and the Zealand university Hospital in Denmark. The sample size for the analysis contains more than 300 patients from different areas.

The samples of primary melanoma patients with progress have been compared with those patients whose primary melanoma did not show any progress. For analyzing the T cell range of tumors, Adaptive Biotechnologies performed high throughput DNA sequencing. It was found that out of all identified variables the T cell fraction (TCFr) was an independent and strong predictor for the patients’ progress condition.

Patients with the same lesion thickness were more at the risk of developing metastatic disease. If the TCFr value is lower than 20 % in the patients, then they are more at the risk of disease progression. On the other hand, if the TCFr value is more than 20% then the risk of disease progression is low in patients.

Read more- Dangerous Effects of Cannabis During Pregnancy Explained by New Research

 The test used in this study is not available at the commercial level for clinical use. It is only used for research purposes. The authors said that the study is retrospective because it took the sample and data of patients that are already available. While the prospective study is that in which data for outcomes is not known and further tests are needed for validation.

Kupper and colleagues imagine that if a test could bring to the clinics then it will improve the patient care and strengthen the results. The test is elegant, simple and quantitative. These types of tests will help us in the future to modify the treatments according to the situation. If the patients have high TCFr then we will benefit him with checkpoint inhibitor therapy. If the value is low in patients, then more interventions are needed.

 

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