While the therapeutic benefits of cannabis products are well-known now, it is easy to gloss over their bioavailability.
The degree and rate at which a specific substance is absorbed into a person’s bloodstream, to make use of it where it is needed, is called bioavailability. Cannabis absorption can be affected by psychological processes and the method of consumption. The lower quantity of the plant will be required to reap its benefits if the cannabis is more bioavailable.
The range of consumption methods of cannabis can partly be responsible for the surge in cannabis popularity. Cannabinoids such as CBD and THC are ingested in oil form which is used to make edibles. Since 60% of the human body is water, resistance in absorption is shown by CBD and THC oils.
Since oil and water are immiscible, the same is also true for cannabis oil and the human body, as it has to travel through an aqueous or watery cellular environment, as explained by a member of the Society of Cannabis Clinicians, and chief medical officer at Hello MD, Dr. Patricia Frye.
The difference in bioavailability in different cannabinoids
CBD and THC have been the focus of investigation compared to cannabinol or CBN. However, the dependence of bioavailability on methods of delivery has been shown by studies.
The penetration of CBD can be increased ten times compared to THC when applied as a topical ointment or transdermal patch. However, the bioavailability of THC is more than CBD, on oral administration or delivery via the lungs. Concentrations of THC in the bloodstream have been reported to be 30-50% higher than CBD, according to a clinical study, after oral delivery as a sublingual spray.
However, there is still a limitation of the bioavailability of THC after oral consumption, with an average of only 4-12%, and an average of 30% when smoked or vaped.
Cannabis consumption methods that can optimize bioavailability
Capsules, soft gels, tinctures, and edibles, although are the most common and convenient, cause limitation in bioavailability.
According to Dr. Frye, the absorption with edibles is unpredictable and highly variable, where only 6% of the dose is absorbed, and the onset can take up to 6 hours with effects lasting for up to 20 hours. Oral administration reduces the need for frequent dosing. Furthermore, it lasts longer than smoking and avoids irritation to the airways or risks of malignancies unlike smoking or vaping.
However, inhalation of cannabis causes increased bioavailability due to the transportation of molecules by vapor particles directly to the alveoli in the lungs. Consequently, the cannabinoids enter the bloodstream rapidly and skip metabolism in the liver.
Intranasal delivery, although a lesser-known method of administration usually used for patients with seizures, helps with the easy absorption of cannabinoids, with an onset of ten minutes, and bioavailability of 34-46%.
Transdermal patches are effective in localized pain relief. Steady infusion of active ingredients is allowed by the patches, to the delivery site, hence reducing the experience of spikes of THC in the patient’s bloodstream.
Although nano-emulsions and micro-emulsions can offer up to 1100% bioavailability, the research is still scarce and the effects of cannabinoid activity at a cellular level by these manipulations are still unknown.
Methods to increase the bioavailability
Combining cannabis products with fats can help boost the absorption of edibles. Frye recommends the combination of healthy fats such as guacamole, hummus, or dark chocolate, with edibles or tinctures.
Increasing the number of puffs causes the enhancement of bioavailability by the minimization of the sidestream loss, for the ones who smoke or vape.
Furthermore, Dr. Fyre suggests the use of the dosage of cannabis as needed, as it is the most cost-effective way to optimize cannabis availability. Fyre further adds that less is more, and excessive dosing may worsen the symptoms one is trying to reduce, due to its biphasic nature.
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Good news for Sciatica patients: CBD oil relieves the pain
The recent studies on CBD oil have unfolded its utility in various fields of medicine. Researches on the effects of CBD oil on sciatica patients show that they can prove to be very useful in its treatment. The results have shown that the oil can work wonders to alleviate the Sciatica pain.
What is Sciatica?
Sciatica is a severe pain caused by disruption in the sciatica nerve. Anything that disturbs the nerve results in extreme and sometimes, unbearable pain.
Sciatica is a nerve that starts at the lower back and extends through the hips and legs to the toes. It sends messages from the brain to the legs via spinal cord. Since, it is a long nerve, patients usually complain of the pain at the lower back, hips, legs and heels.
A compression on the Sciatica causes this severe pain. The major causes of compression are a herniated disk, bone spur on the spine or narrowing of the spine.
What is CBD oil
CBD (Cannabidiol) is a chemical compound that is derived from the Marijuana plant. It relieves the pain without causing any psychoactive or mind-altering effects. CBD oil is made by extracting CBD powder from the marijuana plant. Coconut or olive oil is mixed in it for better application.
The recent researches on CBD oil have revealed its anti-seizure, neuroprotective and pain relieving properties. Due to its wondrous effects on human body, many celebrities advocate for CBD.
Utility of CBD oil for Sciatica patients
CBD oil works by increasing the number of pain modulators that stimulate a response to the pain. Our mind has cannabinoid receptors that modulate the pathways that stimulate a response to the pain and negative emotions.
As sciatica pain arises, the CBD oil applied on the respective part works to reach the brain in order to stimulate a faster response to the pain.
While the Sciatica is a very painful condition, it is mostly treatable with medicines. However, most pain relievers have side effects that cause harm in the long run. In contrast, CBD oil works naturally to enhance the receptors with minimum side effects.
Best CBD oil to relieve Sciatica
Every person’s reaction to different types of CBD oil varies from the other. One cannot say with surety, since what works for some might not work for the others. This is primarily because every person has a different set of genetics, general health and tolerance.
Natural and organic remedies take time to show their reaction. While CBD takes some time to relieve the pain, it is undoubtedly one of the harmless ways to do so.
CBD oil works best when used with the consultation of a doctor. Before buying, one should make sure that the oil contains laboratory verified ingredients.
Who owns the Suspicious Marijuana Farm Near Middleton Home?
The Police discovered a Marijuana Farm near Kate Middleton’s family home in Buckleberry in Berkshire. A power outage led to the discovery of the illegal farming of marijuana right next to Middleton’s 18 acrea estate, on Thursday.
The Middleton Estate
Kate Middleton’s parents, Carole and Michael Middleton, own a £4.7 million Grade II Manor house in Buckleberry in Berkshire. The purchased this property back in 2012 after moving from their £1.5 million house in the same village of Berkshire. The 18-acre estate consists of 7 bedrooms and 5 reception rooms. Carole and Michael moved here due to the better privacy and security this house offered.
The Middleton Family House holds great importance for the Duke and Duchess of Cambridge. The Duke and Duchess have spent a lot of fun moments at ‘The Manor’. All the sweet memories make The Manor a strong fort to hold.
Discovery of the Marijuana Farm
Upon calling, people from the electricity board came to solve the electricity power situation. The workers from the electricity board discovered the Marijuana Farm on the Wednesday night. They immediately brought this to the attention of the police. The police raided the area on Thursday and found an empty Cannabis factory.
A witness reported that about 6 vans collected the content inside the potential cannabis factory. The police has taken all the evidence for further investigation. The Police is investigating this case under the top priority badge. They have found some evidence that the empty and abandoned factory was previously being used as a safe space to make drugs from cannabis.
Until now, no arrests have been made and people are clueless about the owner of the factory. The police has asked the public to contact police if they have any information regarding the suspicious factory hidden in the barns. The investigating officer told the media that they are still carrying out an investigation. They are confident that they will soon get to the bottom of this matter.
As suspicious as it might sound, there is no confirmation to it. Kate Middleton is the Queen of Grace and her family is an epitome of class. The rumors about the Cannabis Factory being owned by the Middletons are circulating however, it seems nothing but a rumor. Royal family has always been subjected to such fake news every now and then. Previously rumors about Kate’s fourth pregnancy were also in the air and Kate having marital issues with Prince William also surfaced.
While the Police and CID are working hand in hand to solve the mystery of the Cannabis factory and marijuana farm right next to the Middleton Family House, people are looking forward to get their hands on the latest gossip.
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