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Could Cannabis Be Used As A Potential Treatment for Inflamation?

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Inflammation, although a life-saving immune response, can also range from unpleasant to downright life-threatening. When a body is injured or infected, the white blood cells rush to the affected area to release signaling proteins for protection, while also pushing out potential pathogen, and then start the healing process.

However, blood flow and spark fluid secretions are increased by these proteins, which cause redness, swelling, and pain, which is inflammation. Inflammation is commonly caused by the false identification of harmless substances, even our tissues, by the immune system, which in turn produces painful and often chronic conditions like arthritis, ulcerative colitis, skin conditions, asthma, and general soreness and joint paint.

Mass-market drugs by the dozen are used for the treatment of inflammation, including over-the-counter aspirin, ibuprofen, and naproxen, that although reliable and effective, carry side effects. Furthermore, herbal and natural remedies have also gained popularity in recent years.

However, even the most popular inflammation treatments have their side effects such as ulcers, liver damage, and kidney damage that can be caused by taking high doses of Advil – with the active ingredient ibuprofen, over long periods.

Furthermore, fluid retention, high blood pressure, mood, and memory swings, and hormonal imbalance, can be caused by steroids – even in the short-term.

Meanwhile, all kinds of inflammation are shown to be alleviated by medical cannabis, which also works in ways that are different from conventional drugs. Cannabis compounds have been shown to suppress cytokines and chemokines – the inflammation-causing proteins, unlike the hormone-mimicking steroids and ibuprofen, which works by blocking prostaglandins (released in the brain in response to injury).

National Institutes of Health funded a comprehensive scientific peer review that was published in the journal, Future Science, in 2009, that explained that compounds in cannabis can identify when and where the immune system is over-reacting, and can hence help down-regulate those responses at the site instead of throughout the body.
The effectiveness of cannabis in particular for inflammatory bowel disease (IBD), is singled out in the review. This disease, not limited to, can include ulcerative colitis and Chrohn’s disease.

Regulation of the tissue response to excessive inflammation in the colon has been shown by cannabinoids. The results suggesting the modulation of the physiological activity of the cannabinoid system during colonic inflammation could potentially be a therapeutic tool for the treatment of several diseases.

130 clinical studies – that mostly involved lab mice, and similar academic reviews and papers are cited by the review. The review concludes that receptors in the endocannabinoid system, are found on the immune system, which is why cannabinoids can play an important role in the regulation of the immune system.

Despite the promising research, clinical trials involving humans have not been performed. Dr. Sue Sisley, the pioneering medical researcher with a groundbreaking study of cannabis for PTSD, has also shown agreement to the general findings of the 2009 review. Sisley’s research, placebo-controlled, blind clinical study that involved more than 70 former US soldiers for their response to cannabis therapy, will help understand the effect of cannabinoids on inflammation in the human body.

According to Sisley, although they have not quantified the degree of anti-inflammation, drawing blood for markers for inflammation, and measuring it pre-treatment and post-treatment, can help see if cannabis has an impact on the inflammatory process.

The results of Sisley’s research will not be revealed until it is completed later this year or early next. However, a positive outcome could cause renewed interest in further exploration of the development of cannabis therapies for inflammation, including the different consumption methods, strains, and terpene profiles that will be best suited for certain types of inflammatory response.

However, Sisley has explained although it is believed that strains high in the terpenes Myrceneand Pinene may have the highest anti-inflammatory effects, there is no proper evidence to support this.

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Texas Passes New Hemp Industry Regulations

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Hemp

Hemp has been a staple of human use since antiquity. Rope is made from fibers of Cannabis sativa, while the leaves and shoots are also used often. However, in Texas, the USA, the absence of stringent regulatory laws in the industry have been noted.

Food, drinks, and cosmetic goods all come from hemp-based cannabinoids like CBD (cannabidiol). For this reason, the Texas Department of State Health has issued a new set of laws and a deadline to conform.

The set of laws include new mandatory licenses and quality inspections

The government had intended to straighten up the hemp industry with two key laws. Both of these laws were put into effect as of August 2, 2020. Firstly, all hemp manufacturers, processors, and distributors must obtain a compulsory license. This license is available for $258 per hemp facility, and it is now illegal to operate without it.

Furthermore, hemp businesses must register the stores where their products are sold by October 2, 2020. This will cost an additional $155 per outlet. Each of these licenses is valid for one year, and they must be renewed upon expiration at the Texas Department of State Health Services website.

Secondly, hemp products are now subject to random inspections. To ensure safety and quality standards, state health officials will carry out tests for safety and quality standards. They will also inspect the THC (tetrahydrocannabinol, the main psychoactive agent in giving users their ‘high’).

This is because the federal legal limit of THC is 0.3%. Aside from this, the state health officials will also look for harmful germs, heavy metals, and chemicals.

Texas still has a ban on the smoking of hemp

Despite the recent laws, it should be noted that Texas’ stance on smoking cannabis is still conservative. Even the consumption of cannabis in food, for the purpose of getting high, is still illegal. The possession of any cannabis product with over 0.3% of THC is still a misdemeanor. The only acceptable use of THC products is as an additive, and these new regulations reflect that.

Despite the legality of hemp, Texas is still a state that only recently allowed this. Hemp was only legalized for industrial use in 2019. This was by the passing of House Bill 1325 last June. Republican State Sen. Charles Perry backed that law.

The law was a major shift from previous conservative stances in the state. This bill legalized hemp distribution, production, and usage for the first time in the entire state’s history.

Increased imports of THC products led to these new regulations

The move to introduce these two new laws was somewhat surprising to most. With respect to hemp, Texas has long been considered among the most conservative states in the country. Hence, it’s only understandable that it would keep the substance banned even as others have legalized it. However, Perry has since gone on to mention why the sudden regulation was implemented.

Speaking in a press release, he stated that the move was made because of increased imports of related goods. Such goods came from countries and states that he believed to have subpar quality assurance. Therefore, the hemp was made safer and more reliable by putting the focus on regulating local producers.

After all, the quality of imports cannot be improved directly. Perry went on to praise the efficacy of his bill. He claimed the new regulations would significantly improve the hemp commercially available.

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American Heart Association Study Links Cannabis To Increased Risk of Heart Disease

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Studies on the effects of cannabis on cardiac health emerged from a scientific paper by the American Heart Association (abbreviated AHA). One of these studies, released on August 12, 2020, refers to THC and CBD. Both of these are key ingredients in cannabis products.

The study finds that there is no clear positive benefit to cardiac health by these substances. A similar study to this mentions a possibly greater risk of strokes or heart attacks in consumers.

Both THC and CBD are held responsible

THC (tetrahydrocannabinol) and CBD (cannabidiol) are both major ingredients in consumable cannabis. THC is the chemical that causes the ‘high’ of the drug, which is arguably the most important aspect of its use. Cannabis is largely considered non-addictive, yet it is still frequently and routinely used.

However, in certain individuals, unmonitored use of cannabis has led to medical emergencies too. In these, hospitals have reported cases of cardiac failure and atrial fibrillation (a type of dysrhythmia).

THC, in these studies, has been linked with over-stimulation of the sympathetic nervous system. What this means is that it can trigger the body’s ‘fight or flight’ mechanism above normal limits. This could lead to anxiety, palpitations (heart skipping beats), and hyperventilation (breathing too fast). Hyperventilation can cause excessive levels of carbon monoxide in the blood, which is also harmful.

Conversely, it seems odd that CBD, on the other hand, seems to have a positive effect on the cardiovascular system. In most findings, researchers consider it responsible for lowering heart rate. Furthermore, it promotes the dilation of blood vessels and reduced blood pressure. So THC, in this case, does seem to be the bigger culprit in heart disease.

However, there is one major drawback in all of these studies. They are only related to patients that smoke cannabis and don’t cover edibles. So, consumers of cannabis-laced foods or beverages may have less to worry about.

The mode of taking the drug can have a dramatic difference in health. These latest studies all indicate that inhalation of cannabis, along with tar and smoke, may worsen effects. In such cases, this undermines both cardiovascular and lung health. These harmful substances can also lead to toxicity by carbon monoxide, and cause respiratory issues.

The studies aren’t meant to be definitive or conclusive

These studies do come from a credible source. However, even the authors and publishers warn that these are not meant to be conclusive. This is because they are based on correlation, not causation.

To put it simply, they indicate that the ingredients of cannabis can be linked to heart disease but not necessarily cause it. Robert Page, who is the author of the paper, admitted this in a recent interview. Rather than evidence they are based on incidences and events, so he called them “observational”.

More studies are needed before we decide if cannabis can be considered safe or not

“…The public needs fact-based, valid scientific information about cannabis’s effect on the heart and blood vessels,” Page claimed. He was referring to the relative lack of such conclusive studies available on the issue. Hence they should be carefully considered, though they are technically valid.

The absence of data on cases of orally ingested cannabis is another limitation of the study is, once again. Most experts already believe that smoking and vaping are quite unhealthy. This is compared to, suppose, just eating a marijuana brownie. So until then, the matter is still up in the air.

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Mike Tyson Helps Launch Cannabinoid Beverage Company, ‘Smart Cups’

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To most, he is known as the former World Heavyweight Champion and established celebrity personality. But Mike Tyson, in a surprising turn of events, has begun a new line of the venture – The manufacturing of 3D-printed cannabis beverages that are called ‘Smart Cups’.

This simple-yet-effective stab at the instant-made cannabis beverage simply requires water. It dissolves the dehydrated cannabinoids, or any other desired substance, that are etched into the bioplastic cup’s bottom surface. 

Smart cups is a game-changer

The intended purpose of a device so convenient lies beyond sheer convenience. Smart Cups aims to safely and efficiently quantify, according to dosage requirements, of the cannabis in the drink. Simply put, a known quantity is added to a great degree of certainty to the consumer, given that dilution is irrelevant.

Increased dose accuracy makes the consumption safer and less unpredictable than traditional routes of administration. For new and inexperienced cannabis users, it potentially spares them of an unpleasant trip.

This concept is concisely summed up in a recent quote from a Forbes interview with the founder of Smart Cups himself, Chris Kanik: “In this specific application, we use water-soluble cannabinoids and are able to precisely print them on virtually any surface…The printed actives and flavors are released when they come in contact with a liquid (be it water, soda, saliva, etc).”

Kanik also went on to compare the Smart Cups’ guarantee of dose accuracy with that of the traditional pharmaceutical industry. He pointed out that aspirin is never doubted in its dosage. (The aspirin is a commonly used drug available over the counter to treat a variety of issues).

This is because of the given strength, for instance, 100mg is universally accepted to be true and reliable. Up until the advent of Smart Cups, he claimed, such a high degree of faith in the product was unmatched.

Tyson Ranch fully backs Smart Cups

Meanwhile, Smart Cups moves on to make a name for itself. And“Iron” Mike Tyson is slated to use his established cannabis enterprise, Tyson Ranch, to bolster the latter’s technology. This shared interest has seen Tyson Ranch make use of their state-of-the-art 3D printing resources to further carry Smart Cups.

Tyson himself said in a recent Forbes interview, “For the Ranch Companies, it is very exciting to be working with Smart Cups’ technology because it gives us the opportunity to make anything that is possible with this innovative tech…”

Tyson expressed faith in the vision of Smart Cups. He named their reliable method to give consumers exactly what they paid for. And not trouble them with unpleasant and sudden over- or under-estimates in terms of the strength. 

That said, there is no official word for when Mike Tyson’s fascinating new product will be available on the market, much less about which regions it will be available in. We advise readers to check Tyson Ranch’s official website for the latest updates on product availability, pricing and more. 

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