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Can Cannabis Replace Benzodiazepines and Opioids?

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Benzodiazepines are powerful medications for anxiety, insomnia, and several other conditions, have implicated in roughly 8,000 overdose deaths in a year. Cannabis could help reduce benzodiazepine dependency and abuse, due to the ability of cannabis to affect the same neural pathways in the brain.

Benzodiazepines are a large class of lab-synthesized drugs, with the inclusion of –

  • Diazepam (Valium)
  • Lorazepam (Ativan)
  • Clonazepam (Klonopin)
  • Alprazolam (Xanax)

These medications are prescribed for conditions like

  • Anxiety
  • Insomnia
  • Nervousness
  • Panic disorders
  • Seizures
  • Muscle spasms

They are also used for sedation during surgery as well as for the treatment of premenstrual syndrome and the symptoms of alcohol withdrawal.

Benzodiazepines are prescribed for acute situations (that includes calming a patient before surgery of the alleviation of the anxiety of a traveler before a flight) and intended for short-term use because they act relatively quickly. However, these drugs are also prescribed for long periods, which leads to a significant number of serious side effects and addiction.

Benzodiazepines are rarely responsible alone for overdose deaths. However, due to their ability to depress the central nervous system (CNS), they can contribute to overdose deaths when taken along with other kinds of CNS depressants such as alcohol or opioids.

Although not fatal, these drugs cause numerous side effects, where the minor ones include dizziness, confusion, problems with memory and concentration, gastrointestinal problems, poor balance, and fatigue. However, serious side effects can include jaundice, severe low blood pressure, elevated heart rate, musculoskeletal problems, and cognitive decline and dementia.

Endocannabinoid receptors, that can bind both to cannabinoids produced internally as well as from external sources such as spices and cannabis, are found in organs and tissue throughout the body. The cannabinoid receptor CB1 occurs widely in the brain, especially in the prefrontal cortex, hippocampus, and amygdala, which all are areas that are rich in GABA receptors.

Anandamide and 2-AG are the body’s natural cannabinoids that produce feelings of calmness and relaxation. Recent research shows that processes that cause a reduction in the release of GABA, can be affected by them the way benzodiazepines do. Furthermore, because natural cannabinoids and cannabinoids from cannabis (particularly cannabidiol (CBD)), bind to the same receptors, they support those processes too.

More effectiveness and safety, compared to benzodiazepines, are shown by cannabis products of all kinds, especially those high in CBD. Although found in relatively large numbers in many areas of the brain, endocannabinoid receptors are notably absent in the brainstem – which is not the case for both opioids and GABA, and which is why cannabis Is highly unlikely to cause or contribute to an overdose death.

Benzodiazepines can override the body’s expression of GABA when used for longer periods. The medications can become addictive and can trigger a series of possibly dangerous withdrawal symptoms when stopped. There is a high addiction risk in benzodiazepines, which is why a majority of drug rehab programs now include the treatment for them.

Meanwhile, few, if any, physical withdrawal symptoms are caused by stopping cannabis. Since all of the functions of the endocannabinoid system (ECS) are affected by cannabis, it gives rise to other positive effects such as immune system support and relief from pain, and the symptoms from various health conditions.

Recent research on cannabis as a substitute for prescription medications has revealed that an incredible majority of cannabis consumers were able to reduce and stop using opioids and also other medications which included benzodiazepines, with the use of cannabis

The documented benefits of cannabis held the inclusion of alleviation of anxiety, relief from insomnia and depression, as well as the symptoms of epilepsy and other disorders that were currently treated with benzodiazepines.

In all of its forms, cannabis has shown to work with the brain’s GABA pathways like benzodiazepines.

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Good news for Sciatica patients: CBD oil relieves the pain

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The recent studies on CBD oil have unfolded its utility in various fields of medicine. Researches on the effects of CBD oil on sciatica patients show that they can prove to be very useful in its treatment. The results have shown that the oil can work wonders to alleviate the Sciatica pain.

What is Sciatica?

Sciatica is a severe pain caused by disruption in the sciatica nerve. Anything that disturbs the nerve results in extreme and sometimes, unbearable pain.

Sciatica is a nerve that starts at the lower back and extends through the hips and legs to the toes. It sends messages from the brain to the legs via spinal cord. Since, it is a long nerve, patients usually complain of the pain at the lower back, hips, legs and heels.

Also read: Who owns the suspicious Marijuana farm near Middleton Home?

A compression on the Sciatica causes this severe pain. The major causes of compression are a herniated disk, bone spur on the spine or narrowing of the spine.

image credits: medium.com

What is CBD oil

CBD (Cannabidiol) is a chemical compound that is derived from the Marijuana plant. It relieves the pain without causing any psychoactive or mind-altering effects. CBD oil is made by extracting CBD powder from the marijuana plant. Coconut or olive oil is mixed in it for better application.

The recent researches on CBD oil have revealed its anti-seizure, neuroprotective and pain relieving properties. Due to its wondrous effects on human body, many celebrities advocate for CBD.

Utility of CBD oil for Sciatica patients

CBD oil works by increasing the number of pain modulators that stimulate a response to the pain. Our mind has cannabinoid receptors that modulate the pathways that stimulate a response to the pain and negative emotions.

As sciatica pain arises, the CBD oil applied on the respective part works to reach the brain in order to stimulate a faster response to the pain.

While the Sciatica is a very painful condition, it is mostly treatable with medicines. However, most pain relievers have side effects that cause harm in the long run. In contrast, CBD oil works naturally to enhance the receptors with minimum side effects.

Best CBD oil to relieve Sciatica

Every person’s reaction to different types of CBD oil varies from the other. One cannot say with surety, since what works for some might not work for the others. This is primarily because every person has a different set of genetics, general health and tolerance.

Natural and organic remedies take time to show their reaction. While CBD takes some time to relieve the pain, it is undoubtedly one of the harmless ways to do so.

CBD oil works best when used with the consultation of a doctor. Before buying, one should make sure that the oil contains laboratory verified ingredients.

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Who owns the Suspicious Marijuana Farm Near Middleton Home?

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The Police discovered a Marijuana Farm near Kate Middleton’s family home in Buckleberry in Berkshire. A power outage led to the discovery of the illegal farming of marijuana right next to Middleton’s 18 acrea estate, on Thursday.

The Middleton Estate

Kate Middleton’s parents, Carole and Michael Middleton, own a £4.7 million Grade II Manor house in Buckleberry in Berkshire. The purchased this property back in 2012 after moving from their £1.5 million house in the same village of Berkshire. The 18-acre estate consists of 7 bedrooms and 5 reception rooms. Carole and Michael moved here due to the better privacy and security this house offered.

Image Credits: Zimbio.com

The Middleton Family House holds great importance for the Duke and Duchess of Cambridge. The Duke and Duchess have spent a lot of fun moments at ‘The Manor’. All the sweet memories make The Manor a strong fort to hold.

Image Credits: express.co.uk

Discovery of the Marijuana Farm

Upon calling, people from the electricity board came to solve the electricity power situation. The workers from the electricity board discovered the Marijuana Farm on the Wednesday night. They immediately brought this to the attention of the police. The police raided the area on Thursday and found an empty Cannabis factory.

 Also read: House Fire exposes illegal marijuana operation

A witness reported that about 6 vans collected the content inside the potential cannabis factory. The police has taken all the evidence for further investigation. The Police is investigating this case under the top priority badge. They have found some evidence that the empty and abandoned factory was previously being used as a safe space to make drugs from cannabis.

Until now, no arrests have been made and people are clueless about the owner of the factory. The police has asked the public to contact police if they have any information regarding the suspicious factory hidden in the barns. The investigating officer told the media that they are still carrying out an investigation. They are confident that they will soon get to the bottom of this matter.

Also read: WHO – New Study Suggests Face Mask Could Reduces the Risk of COVID-19 by 85%

Baseless Rumors

As suspicious as it might sound, there is no confirmation to it. Kate Middleton is the Queen of Grace and her family is an epitome of class. The rumors about the Cannabis Factory being owned by the Middletons are circulating however, it seems nothing but a rumor. Royal family has always been subjected to such fake news every now and then. Previously rumors about Kate’s fourth pregnancy were also in the air and Kate having marital issues with Prince William also surfaced.

While the Police and CID are working hand in hand to solve the mystery of the Cannabis factory and marijuana farm right next to the Middleton Family House, people are looking forward to get their hands on the latest gossip.

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COVID-19 – Florida Medical Cannabis Industry Sees Significant Sales Spike

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Despite the global pandemic and its consequences, the medical cannabis industry of Florida continues to flourish. Moreover, sales have increased in comparison to sales before the outbreak. Medical cannabis has gained popularity with a consistent increase in demand. Consequently, this gives an appropriate example regarding the stability of the cannabis interest despite the times of an economic crisis.

Weekly sales of medical cannabis in Florida

The first 2 months of 2020 were somewhat a state of normalcy. This was the time when the outbreak was under control. Hence, no government was forced to take drastic measures such as global lockdown, economic shutdown, etc. During the time, the sales in the dispensaries in Florida were on an average of 22,800 ounces of smokable MMJ weekly.

While these sales were during the first 10 weeks, the next week of March 13 recorded higher sales. There was a trade of 36,400 ounces during the week of March 13. That resulted in a rise of 38% in sales compared to the last week. This was the week when COVID-19 became a global concern and many countries began to issue stay at home orders.

Florida Medical Cannabis

Florida Office of Medical Marijuana Use

Florida’s program records the sales figures generated starting from Friday and ending the following Thursday, to create a weekly sales report. However, the week of April 17 was another essential week to record sales. During that week, the Florida program recorded that sales in Florida resulted in a combined 39,290 ounces of the flower.

The sales during that week could be understandable due to the 2 sales boosters that aligned. The first was the initial round of the COVID-19 relief fund. During this time, the stimulus checks happened to be the primary issue that Americans’ bank accounts dealt with. The second was the cannabis holiday, 4/20, which is unofficial due to the current laws.

The statistics

The market’s experience of a rise in sales on a weekly basis was not infamous. However, there was a record of consistently higher sales during this pandemic in comparison to the time before. Moreover, the rise in consumption led to this consistent period of the rise in demand. Both existing, and new patients, led to the rise in consumption.

The data available regarding the sales made in the first 10 weeks of 2020, led to the generation of an average figure. It was determined that the average medical cannabis patient obtained the average amount of 2 grams of the flower, weekly.

There was a rise in the figures during the past month in total, or the 4 weekly reports, from May 1 to May 28. The average medical cannabis patient, on average purchased 2.9 grams. This resulted in a rise of 43%.

Legal actions taken by the government

Furthermore, due to tot the global lockdown and economic crisis, there was a delay in many legal processes. However, the government recently granted permission to the medical cannabis patients for the renewal of their registrations. There were restrictions regarding the renewal which still banned in-person communication but encouraged teleconference for the renewal. However, Florida’s Office of Medical Marijuana Use did not reportedly take any substantive actions for the strengthening of the industry during a crisis as such.

The state included medical cannabis dispensaries in the list of essential businesses. The Florida government released the list early in the pandemic, in March and included the unaffected companies and businesses during the lockdown. Hence, Florida’s medical cannabis retailers continued the delivery of their cannabis products to patients.

There are different concerns that come along. The question that arises, however, is if this rise in both Florida’s medical cannabis market, and the cannabis industry generally, will be consistent or not. he cannabis industry hopes for the restoration of the economy before their added, shifting coronavirus unemployment advantages cease.

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