Following the increase in its legal and social acceptance, cannabis is also gaining renewed attention in the medical world. The relaxation of barriers surrounding the industry has not only expanded its economic foregrounds but has also enticed various researches into its medicinal viability. In one such recent attempt, scientists from the UT Southwestern Medical Center have discovered that among many other things, cannabis can also soothe several bowel conditions, including inflammation and gastrointestinal infections.
The study was conducted under the leadership of Vanessa Sperandio who is associated with UTSW as a professor of microbiology and biochemistry since 2001. Together with her team of scientists, Vanessa Sperandio has uncovered how cannabis and marijuana work to lessen the symptoms of various bowel conditions and improve the body’s resistance towards pathogenic bacteria that attack the gut.
In order to understand the results of her study, it is important to understand the mechanism of the body’s endocannabinoid system. Here’s how it works:
Role of Cannabinoids in the Endocannabinoid System
Cannabinoids are a comprehensive class of chemical compounds that are produced by numerous biological species, including humans and plants.
In humans, cannabinoids form a vital part of the endocannabinoid system, which regulates a number of functions in the body. These functions include mood and appetite regulation, inflammatory responses as well as reproduction and fertility levels in the body. The ECS also involves two other core components: receptors and enzymes. Without a smoothly functioning ECS, achieving a state of homeostasis would be next to impossible for the physiological well-being of the body.
In general, cannabinoids that are produced within the human body are referred to as endogenous cannabinoids or endocannabinoids by scientists. The cannabinoids obtained from external sources such as plants, particularly cannabis, are addressed as ex0genous-cannabinoids for the body.
It is interesting to know that the chemical structure of endocannabinoids is very similar to the cannabinoids that are produced by plants (phytocannabinoids). While these classes of cannabinoids may be structurally similar, their properties vary considerably.
Endo and phytocannabinoids bind very differently to the cannabinoid receptors present throughout the body. They also activate the endocannabinoid system in different ways. While endocannabinoids activate a homeostatic effect, phytocannabinoids have the chemical ability to produce certain medicinal effects on the body. These effects may be psychotropic and therapeutic in nature, depending upon the source of the phytocannabinoid.
Some phytocannabinoids like THC may have psychoactive effects, making users feel euphoric or high. In contrast, other cannabinoids like CBD may produce the same therapeutic effects of THC, minus the “high” factor.
Findings of the Study
The study conducted by UTSW showed that cannabinoids were helping to block genes of pathogenic intestinal bacteria. This inhibited their colonization and multiplication, stopping the infection from spreading further.
To arrive at their conclusions, the researchers genetically modified mice to overproduce the 2-AG cannabinoid. This is one of the major types of endocannabinoids that signals the central nervous and regulates neurotransmissions in the ECS. Afterward, these mice were infected with a bacterial pathogen that typically attacks the gut, causing severe inflammation and diarrhea.
The results showed that the genetically modified mice had lower inflammation levels and signs of infection in their bodies. Their results were compared with other mice that had lower levels of the 2-AG cannabinoid in their bodies.
Higher levels of the 2-AG cannabinoid also restricted infections caused by Salmonella typhimurium and Escherichia coli bacteria. In addition, this cannabinoid also blocked QseC, a bacterial receptor that causes C. rodentium, S. Typhimurium, and E. coli. In contrast to this, when mammalian cells were tested in a petri dish, inhibition of 2-AG using Alli, the mice became more prone to bacterial infections.
Some studies have also shown that cannabis can help to counterbalance the disproportionate inflammatory response of the gut. Since some bodies lack the ability to naturally produce enough cannabinoids to control inflammation, bowel diseases like IBD and IBS may occur. Using cannabis to soothe these bowel-related illnesses can be the solution patients and doctors were waiting for.
Four Tips to Secure Cannabis Dispensaries in Oregon Today
Since the chain of cannabis crime is being beaded at a much faster rate in Portland, Oregano, there is a dire need to enhance the security measures. Robbery of a cannabis dispensary is as money-spinning as of a bank. Until an act is passed to allow the transactions, cannabis dispensaries remain the prime target of a robbery as all dealings continued to be done in cash.
Tips to Fortify Cannabis Dispensaries Security
The recent report by the Oregon Liquor Control Commission showed almost 120 robberies since march 2020 in Portland Metro alone. It resulted in a total loss of $500,000 in terms of both products and cash. To strengthen the security around the dispensary in a quick and easy way, a key step is to install rolling doors to keep criminal activities at bay.
Tip #1 – Tight Security Measures at Storefront
One of the most popular yet helpful ideas to prevent looting is to install heavy-duty steel doors, which can help add an extra layer of protection for the cannabis business. The plus point is that the manufacturer can directly mount it into the already existing buildings exteriorly. Also, these are significantly helpful in protecting the glass windows, which can be expensive to replace.
What’s more, it can block the view of the thieves to the merchandise. These are different from the other standard rolling grills. With these, the criminals won’t be able to see the stockware when the door is closed. Some of the dispensaries have tested their door against the Department of Defense to assure that even no violent attack can harm them. These doors are lift- and pry-resistant.
Tip #2 – Need of Visibility and Ventilation
If the cannabis dispensary owner wants to let the outside world see their merchandise, there is a need for more robust security. With compact impact glass and a heavy-duty grille, it is possible to stay away from the world’s sight when needed.
Easy custom orders and installation makes it an excellent choice to adhere to the security demands. Heavy-duty grilles that have rods closely spaced and strong interconnections are difficult to lift and attack than the standard grilles.
The rolling grilles become even a much better option to protect the counters in the cannabis dispensaries. There is no need to do any modifications to adjust it behind the glass door. It can be easily installed in small places where the ceiling is low.
Tip #3 – Separating Cannabis Dispensary from the Store
Cannabis dispensaries in the high-end stores need extra protection, and thus, important to separate them from the rest of the shop. Cannabis dispensary separated from the rest of the shop can have different operational hours like some states have specifically specified.
The mesh metal grilles look much better and significantly affect the aesthetics of the store. It can deliver both beauty and security while customers can easily view the cannabis products of the store. There are manufacturers who are even designing logos on the grilles to give aesthetic pleasure.
Tip #4 – Secure Delivery to and from Cannabis Dispensaries
The cannabis dispensary owners usually tend to forget about secure deliveries that are most prone to attacks. Deliveries being made at the store back and the receiving areas are usually the areas of concern. It is extremely important to track down the time of delivery, people present there, and the stock delivered.
The heavy-duty service rolling doors provide exceptional security than those traditional sectional rolling doors. They are made to meet the demands of beauty and security, both as they are highly customizable and can be easily adjusted to limited spaces. They offer the idea of security by using stainless steel, galvanized steel, and aluminum in the grilles.
Impaired Driving: A Must Consideration for the State’s Cannabis Bill
Even with the concept of Vision Zero and more raising concerns for the traffic rules, Albany legislators aren’t focused on it, while rushing to legalize the use of cannabis in New York. Silive shares the thoughts of how important it is to slow down the process of legalization and first pass on a bill that would stop impaired driving and hold marijuana-impaired drivers accountable for accidents.
Before the legalization of marijuana, to create a safer environment, it is extremely important to put pressure on the notion that studies categorize all intoxicating substances as unsafe for driving.
Impaired Driving Same as a Speeding Ticket
No consideration against the impaired driving would make people think it unimportant as a speeding ticket. This indirect message by the leaders would eventually lead to a greater number of casualties with each passing day.
It is nothing but a truth that marijuana has the potency to affect concentration, response time, motor function, and movement. Also, the science links a high concentration of THC in the blood due to cannabis intake to impaired driving. Surprisingly, marijuana is a second substance that has a major influence on driving capability after alcohol.
Need to Reinforce the Drug Definition in New York
Apart from considering classifying impaired driving due to marijuana as a minor criminal act, some light should also be shed on revising the term drug as other 45 states have done. Any substance should be called a drug that can compromise the ability to think, focus, and react.
If this act is not taken, according to the law, they cannot be charged if the alleged impaired drivers refuse to have a chemical test. The dismissal would eventually result in chaos and poor law enforcement. Such impaired drivers could not be held accountable and would be back on the roads again, risking the lives of hundreds of people.
The legislators of Albany must think about the message they are conveying to the younger generation out there. Already, as shown by the personal accounts of many teenagers, marijuana is nothing big for them and seems harmless.
Different treatment for impaired drivers than those drunken drivers would further strengthen this perception among people. Since neighboring states have already legalized marijuana for recreational and other purposes, New York seems to be next.
Strict Laws and More Investment in the Traffic Sector
Along with the modifications in the law to serve a better criminal justice system, there is a need to pass on better provisions to ensure safety on roads. No person should become a target of people managing a 3,00 pounds vehicle while being impaired by marijuana, asserts the source.
There should be provisions in the law to hold such people against the criminal act. To run a smooth traffic system, it is mandatory to design out complete traffic safety rules. There should be more people, funding, and resources to train the Drug Recognition Expert (DRE) officers and create awareness of the possible effects of drug abuse, including marijuana. As time has changed, the use of synthetic drugs has made it difficult to articulate a specific one; thus, the need for DRE officers has become as important as the need to include the provisions in the bill.
The legalization in New York for cannabis should be set straight from the start. Before the bill includes and assures safety on roads, the legalization of recreational cannabis is a non-starter. All the roads
Cannabis Sales Reaches Skies, Set Highest Mark With $17.5 Billion Sales
The novel coronavirus has been devastating for most industries. For some industries, however, it was bliss. Concerning cannabis, 2020 was a breakout year. Across the United States, 15 states granted permission for adult use, while 35 states allowed medicinal use of cannabis. According to a recent report by Forbes, there was a 46% incline in cannabis sales and use in comparison to 2019, with a budget of $17.5 billion.
Cannabis Sales Increase In Different States
Generation of sales or profit occurs from both medical and adult-use of cannabis. However, recreational or adult-use generates the highest portion of sales, especially in markets like the Colorado marijuana market. In Colorado, the sale of marijuana increased by 26 percent resulting in business involving $2.2 billion.
According to BDSA, an improvement in sales of Oregon occur by 29 percent from 2019. Moreover, the Oregon market makes a business of $1.1 billion. The cannabis market in Illinois is under progress and development. Yet, it was able to achieve the highest sales in 2020.
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Moreover, during 2020 Illinois marijuana industry expanded from medical use to adult use. As a result of legalizing adult-use, an increase of $784 million occurs in sales. Besides, now Illinois is doing sales of over $1 billion in its marijuana market.
Sales in California and Florida also increased. $ 586 million increase in sales of marijuana in the California market occurs, a total of about $3.5 billion business is happening in it. Moreover, the rise of $473 million occurs in the Florida marijuana market.
What causes The Rise In the Economy Of the Marijuana Industry And Market?
According to BDSA’s insights and analytics department, the cannabis industry is recession-proof and continues to progress. Moreover, it has the most potential of evolving and flourishing.
According to Kelly Nielsen, the rise in the marijuana industry was due to three reasons. Firstly, during the coronavirus pandemic, dispensaries were major-businesses, and many individuals built their own.
Secondly, more devoted customers enter big markets like California, Colorado, and Oregon. Third, multiple states legalize the use of cannabis for both medical and adult use. As a result, the overall sale of marijuana products increased remarkably in the previous year.
Moreover, another major factor is that individuals have begun to consume cannabis in larger amounts. Furthermore, more and more people are now involved in marijuana consumption.
Cannabis users agree that their consumption of cannabis has increased by 25 percent since the beginning of the COVID-19 pandemic. Additionally, the demand for cannabis in legal markets has risen since legalization. According to Nielsen, alcohol penetration is 60 percent, while marijuana penetration is 50 percent.
Cannabis Industry Achieves Mega Sales Hits
Urban Leaf co-founder Josh Bubeck states that 2020 has been a tough year due to the coronavirus pandemic. However, Urban Leaf was able to enhance the market penetration of its cannabis products from 37% to 39%. Moreover, according to Bubeck, the company had its best sales during the last week.
Cannabis companies that have dispensaries at the places of tourists’ attraction suffer the most losses. Similarly, Urban Leaf‘s flagship location near Sea World suffered the biggest-drop.
The legalization of marijuana enables doing business legally and prohibits doing illegal activities. As a result, legal-activities rise, and the pressure of high demand in legal setup rises. Similarly, the closing of illegal dispensaries moves more individuals towards legal dispensaries, leading to a further rise in sales.
Like other cannabis companies, Sava also gets involved deeply in the market. Moreover, according to the founder of Sava, the company observes 60% more growth in their sales during 2020.
According to Andrea Brooks, people are getting comfortable with new legalization and decriminalization policies. Moreover, as people are getting-used-to cannabis policies, the demand for cannabis products is rising, and so are its sales. Despite large profits and sales during the pandemic, no marijuana industrialists want to relive the stressful 2020.
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