Just like endocannabinoids, hormones are biochemical messengers engaged with numerous parts of our physiology. Our development, behavior, sexual capacity, energy utilization, and mood are altogether influenced by hormones. Indeed, even our ability to assess the threat and elaborate a proper response relies on these compounds.
These characteristic controllers are delivered by the endocrine system in organs, for example, the thyroid, pancreas, pituitary organ, nerve center, ovaries, and testicles. The hormones discharged by these organs incorporate melatonin, testosterone, insulin, glucagon, epinephrine, and numerous others. For instance, cortisol is the hormone that manages our response to stress and tension, while melatonin shows to our body when it’s an ideal opportunity to rest and when to wake up. Internal or external factors, for example, stress, sustenance, and chemicals can unbalance the creation of these messengers.
Our endocannabinoid framework is firmly connected to the endocrine system. Studies have demonstrated that the endocannabinoid framework activates receptors in the endocrine system. Studies have also shown that the cannabinoid receptors have been found in many different endocrine glands. Thus, CBD too can active endocrine receptors in the cerebrum, as much as throughout the body.
Studies have demonstrated that cannabinoid really interfaces with the endocrine system, influencing processes like sleep cycle, stress signs, digestion, and sexual activity. A few investigations even demonstrate that endocannabinoids can control the proliferation of various sorts of endocrine malignant growth cells, prompting antitumor impacts. Specifically, they can restrain cell development and metastasis in certain sorts of oncologic diseases, for example, thyroid, breast, and prostate tumors.
The connection between cannabinoids and hormone production recommends that these common compounds may have therapeutic potential for treating endocrine disorders. One of the numerous challenges for cannabis science today is to see how the endocrine system can be balanced by CBD and different cannabinoids so as to regulate hormone levels.
CBD and metabolic hormones
Diabetes is one of the most widely recognized endocrine diseases. It is caused by reduced insulin production in the pancreas. Imbalance insulin can cause many disorders such as diabetes, heart problems, and obesity.
A wide range of studies has investigated the impacts of cannabinoids on metabolism, as well as the connection between the CBD and diabetes. Some of them have demonstrated how CBD impacts the level of insulin in the pancreas, by affecting the glucose level. Given this newly discovered role of endocannabinoids in endocrine regulation and energy balance, the improvement of a CBD therapy in maintaining the insulin level can be one of the next big things for cannabis medicine.
CBD and sleep hormones
In about a couple of years, CBD has become widely recognized for its capacity to treat stress and nervousness. That is on the grounds that among its biochemical interactions with our body, cannabidiol can likewise impact cortisol levels.
Likewise, CBD may stimulate the emission of sleep hormones like melatonin by activating receptors in the pineal organ, in this way improving sleeping routines. Moreover, the adrenal deficiency and subsequent weakness that happens when the adrenal organs can’t discharge enough cortisol and aldosterone might be combated by consuming CBD.
Endocanna Health Aims To Increase Genetic Risk Awareness For COVID-19
This pandemic is practically unprecedented in terms of how mysterious its risk factors are. While the mode of transmission is known, the exact factors that make a person susceptible to severe complications aren’t. Experts all agree that COVID-19 may either pass the infected with no symptoms, cause mild respiratory effects or in worst-cases deaths.
However, what still remains unclear is who is vulnerable and why. That’s why Endocanna Health, a cannabinoid DNA-research company based in California, has stepped up. They are offering a free DNA test for genetic factors in their consumers. This test is meant to scan for known genetic markers that could lead to susceptibility. While the gesture is generous, it must be cautioned such a test is not meant to be a reliable tool to assess this.
DNA research works by looking for known markers
The aim of Endocanna Health’s test is to examine possible vulnerable genes. Such genes could make a person’s immune system weaker to infection, or allow them to develop worse symptoms.
However, if you’re wondering why you haven’t been prescribed this test before, there’s a reason. Most healthcare providers and experts don’t rely on such tests because they only indicate correlation. There is no way to prove the causation. What that means, simply, is that certain genes can make COVID-19 more severe, not always. Factors like age, diet, health conditions and mental health are important too, though.
Endocanna Health’s research is most notable for its work on the human endocannabinoid system. This system includes the way certain cannabinoid neurotransmitters work to regulate mood, sensation, memory, metabolism and immunity.
The system was discovered by scientists investigating the effects of THC in marijuana on the body. While we did just mention immunity back there, it must be kept in mind that this is only part of it (more on that later).
The company’s Chief Science Officer, Dr Chris Spooner, recently claimed that the work they were doing would be useful for understanding the immune system. He mentioned the presence of cannabinoid receptors in the immune cells, that affected the strength of immune response to COVID-19. While the role of cannabinoids on the cells is clear, the message behind the aims should be scrutinized.
Your genes are not the most important factor in beating COVID-19
If Endocanna Health’s aim is to combat COVID-19, then that’s commendable. But if they think that it will significantly contribute to flattening the curve, their hopes are a tad misplaced. Major health experts, from Dr Anthony Fauci to the WHO, all assert that the number one rule to follow is to stay healthy and socially distance. If you’re worried about COVID-19, or another similar disease, then eat healthy, sleep well and stay home. DNA tests can be helpful, truly, in the case of congenital disease (think cystic fibrosis or hemophilia). But to cause misinformation about them is deliberately harmful. Let’s look at the real unsung heroes in the body’s immune system.
To fight infection, circulating white blood cells (called leucocytes) detect and attack germs. They also signal the release of chemicals like prostaglandins to create inflammation and fever, which can be beneficial.
Other cells, like mast cells, help signal the response to rest of the system. Then, from the antigens of the germs, ‘B-Cells’ create antibodies. Antibodies are basically drugs to kill off any other germs left, from bacteria to coronaviruses. This whole process is wonderfully self-regulated. And knowing your genes will just make you more paranoid than actually help, it seems.
Airborne Coronavirus is Infectious, Scientists Say
Previously, it was believed that coronavirus can only spread through microdroplets released during a cough or sneeze. However, a recent study has shown that the tiny droplets released during talking or breathing can also be infectious.
Coronavirus has been on the rise for almost a year now. The epidemic started in China and has now spread to over 100 countries worldwide. Currently, the virus has affected over 15 million people and caused more than 600k deaths.
Despite numerous efforts, the virus is still spreading, with thousands of new cases emerging every day. Several governments have pushed their countries into lockdown and numerous precautionary measures have been made mandatory. These include wearing a mask at all times, maintaining a minimum distance of 6 feet from other humans and washing face and hands several times a day.
Coronavirus was believed to spread through droplets released during a cough or sneeze. However, a recent study has shown that even breathing and talking can release microdroplets that are infectious. They can actively play a role in the spread of the infection.
The study was conducted by researchers at University of Nebraska and was published in an online medical site. The group observed coronavirus obtained from microdroplets and found that it was able to replicate in the laboratory environment.
This showed that the virus can easily travel past the 6 feet distance regulation employed by the governments as a part of their social distancing scheme. Further, it also gives weight to the theory that talking, or breathing can lead to the transmission of the virus.
The study was posted on the medrxiv website, which contains some cutting-edge papers for treating the virus, published since the beginning of the epidemic. However, the study is still in preliminary stage and needs to be peer-reviewed before it can be published in a more credible medical journal.
The same research team also compiled findings about the nature of the virus during its early stages. It is set to be published on an online forum as well. The study showed that the novel coronavirus has the tendency to stay airborne in hospital rooms even after the COVID patients have been discharged.
According to Joshia Santarpia, the lead author of the study, the sample collection process for the studies is extremely difficult. The concentration of the virus in the samples are generally really low, which makes it very hard to recover any valuable information.
The research team used a small device, similar to a cell phone, to collect the samples. Specimens were taken from about a foot above the bed, in 5 rooms with bedridden COVID patients.
The aerosols produced by the patients during talking were collected and had a typical diameter of about one micron. The specimens were placed in a culture to see if the virus was able to thrive. Three out of the 18 samples showed virus growth.
This proves that even breathing or talking around coronavirus patients can significantly increase the risks of developing an infection. The 6 feet rule is not very effective and complete isolation of the COVID patient should be practiced in order to minimize the chances of infecting the people around.
NHS To Launch Other CBD Products For Epilepsy After Epidyolex
The legalization of cannabis has become a major concern due to its medicinal purposes. Therefore, NHS is making moves to help severely affected children with epilepsy by manufacturing their own cannabis oil for clinical trials. Because cannabis is rich in compound cannabinoids, it may be effective for inducing some anti-seizure quality in the body.
In 2018, cannabis was legalized in the UK for only medical purposes. This unanimous decision came after many families claimed how CBD oil has helped their children to combat the life-threatening seizures every day.
The National Institute for Health and Care Excellence (NICE) shared its recommendations related to medical cannabis in November 2019. Epidyolex by GW Pharmaceuticals’, is the only approved epilepsy medication given to children in specific cases.
Patients going through Lennox-Gastaut and Dravet syndrome can refer to schedule 5 of the Controlled Substances Act 2018. Cannabis is on schedule 2, allowing it for medical use and further research on its derivatives.
Need for approval by clinical trials
Even after legalization, NHC did not provide any prescriptions for authentic cannabis products. This has led to uncertainty among the health care system. The piece of evidence is insufficient to make health care workers confident about the potency of cannabinoids for epilepsy.
Due to this fact, the patients are heavily relying on private clinics. Private prescriptions cover large expenses and require hundreds and thousands of pounds every month. NHS has addressed the cause and is planning on making its own cannabis oil for the next clinical trial.
Professor Stephen Powis, the medical director of NHS England, asserts that work is going on this randomized clinical trial to get an idea of cannabis effectiveness.
Medical bosses hope the trial will be enough to give health care professionals sufficient evidence and the right to write free cannabis prescriptions. However, besides NHC, they are also working on small manufacturers, who can provide medicines for the trial.
NHC is eager to design its own oil with a safe amount of THC to avoid making the users high. THC and CBD together make a unique combination to reduce the number of seizers in severely affected children. It may also show significant results against multiple sclerosis.
NHS Took Longer than Expected to Provide Evidence
To overcome this irresolvable issue, NHC is planning to make contributions to the clinical trial next year. However, the parents assert that even if the clinical trials prove to be successful, it is too late for them. They have already spent a lot of money on private prescriptions.
Even though the NHC is taking this issue now seriously, it took too long to respond to evidence. Sir Mike Penning, medical director and chairperson of the All-Party Parliamentary Group on Medical Cannabis under Prescription, blamed medical bosses for delaying and looking at the issue from the wrong side.
After two children receive the cannabis oil under the law, every parent is eager to make necessary arrangements for their children so that they do not die. Since Mike Penning is a conservative guy, he accuses the medical staff of it.
Since a change in UK law in 2018, a separate body deals with the prescription-related cannabis issues. Billy Caldwell received his prescription from the NHC after his mother Charlotte raised her voice against it.
Charlotte says Billy has always made her proud, and this cannabis oil has further helped him to live a normal life. The NHC has not yet confirmed the manufacturing of the cannabis oil but assures that steps are being taken to provide an evidence-based clinical trial.
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