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Trial shows a possible cure for a rare blood cancer type

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A recent clinical trial has shown positive results for a treatment plan for a rare form of lymphoma blood cancer.

What is Lymphoma?

Found in humans, Lymphoma is one of the most common types of blood cancer. Developing from a group of lymphocytes, the cancerous growth occurs around the lymph nodes, causing them to enlarge. However, a rare subtype of the cancer – Intravascular large B-cell lymphoma (IVLBCL) is sometimes hard to diagnose. Hence, leading to a relatively high mortality rate.

IVLBCL is a form of ‘extranodal malignant non-Hodgkin lymphoma (NHL)’, that causes the lymphoma cells to grow within the capillaries and small arteries or veins. Since the growth takes place inside the blood vessels, the cancer is extremely difficult to diagnose. Particularly during its early stages of developement. Further, the presentation of symptoms is generally non-specific, which makes the diagnosis even more challenging.

As of date, there is no effective treatment for IVLBCL. Since, it mostly develops in senior citizens, the patients are not able to withstand the side effects of extensive chemotherapy. Hence, majority of the patients end up denying the treatment altogether. There is an elevated risk of developing permanent “central nervous system” disorders, even after the treatment.

Also read: New Mexico – Governor in Favor of Legalization of Recreational Cannabis

Numerous studies have focused on finding a possible treatment for the disease, however, nothing significant has been developed so far.

Clinical Trial

A group of researchers from Mie University and NogoyaUniversity, Japan, recently tried to test a new treatment plan that would effectively target the cancer and also minimize the side effects. The study analyzed the patients’ data and concluded that those who underwent chemotherapy combined with “rituximab” drug, showed promising improvements in their overall condition.

However, it still does not prevent or reduce the secondary side effects on the central nervous system. According to Dr. Kazuyuki Shimada, “We considered that rituximab-containing chemotherapies combined with treatment for the secondary CNS problems could lead to further improvement in the clinical outcome.”

The trial consisted of 38 patients between the ages of 20 and 79. They were diagnosed with the Intravascular large B-cell lymphoma but were not showing signs of any central nervous system disorders. The subjects were monitored over several years and the finding were published in a scientific paper, The Lancet Oncology.

Results

The treatment procedure showed some positive results. Out of the total patients, 76% reached the two year survival goal without the progression of disease, whereas 92% reached the overall survival goal. The treatment significantly reduced the overall side effects and only 3% of the patients showed CNS damage. The team also reported that there were very few serious complications that occurred during the trial, especially in comparison to the average number of complications with a standard treatment.

Also read: Ontario Begins Virtual Inspections for Cannabis Stores During Lockdown

Dr. Shimada summarized the findings, saying, “It appears that the proposed treatment protocol might be effective in patients without apparent central nervous system involvement at the time of diagnosis.”

However, further research needs to be done to come to any definitive conclusion. Especially, since the trail group was very small, and the results might be purely coincidental. Despite that, the treatment can stills be employed in clinical practices, since it does not use any ‘novel’ drugs – i.e. all the compounds used are already being used for IVLBCL’s treatment across the globe.

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Cannabis

Cannabis Found Effective in Treating Pain With Zero Side-Effects

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Recent Researches on Cannabis revealed its efficacy in Treating Pain with zero side-effects. A survey conducted as a part of this researched showed that patients experienced relief using cannabis for pain.

An Effective Substitute of Opioid

The survey also showed that Cannabis has greatly substituted Opioid. Opioid is a harmful drug which is used for managing pain. Previously, Opioid was the only drug effective in treating pain. However, it had a lot of side-effects. It causes drowsiness, mental fog, nausea, and constipation. It can also cause slowed breathing, which can lead to overdose deaths.

The daily use of cannabis in patients showed prolonged improvements in pain management and increased quality of life. In just a short interval of only three months, patients began to feel improvement in overall physical and mental health.

Effectiveness of CBD Oil in Pain Management

CBD (Cannabidiol) exists as a chemical compound which is obtained from the cannabis plant. Moreover, it decreases the pain with no development of any mind-altering or psychoactive effects. Additionally, CBD oil is produced by the extraction of CBD powder from the cannabis plant. Recommendations involve the use of olive or coconut oil, as a mixture, for better use.

Also Read: Good News For Sciatica Patients: Study Reveals Effective Results of CBD Oil

The latest studies on CBD oil have unveiled its neuroprotective, anti-seizure, and pain relieving qualities. Owing to its remarkable impacts on the human body, several celebrities are advocating for CBD.

Worldwide Legalization of Cannabis

It is important to remember that 33 states of the U.S. have legalized the use of medicinal Cannabis while 11 states have legalized the use of medical Cannabis.  With these recent legalization, the demand and supply of cannabis increased by multifold. Increased demand led to increased research on the subject.

Also Read: Asian Visitor Caught Smuggling 6kgs of Cannabis in Dubai

Cannabis has found many uses in our daily lives. It can treat something as painful as Sciatica Pain. The use of Cannabis can alleviate the frequency of seizures. It also reduces anxiety. it helps with the PTSD. Many people have found Cannabis useful in calming their nerves and dealing with insomnia.

COVID-19 & CANNABIS

In view of the recent pandemic, COVID-19, Cannabis has also found its utility in speeding up the recovery of COVID-19 patients. COVID-19 is a highly infectious disease that has infected over 11 million people in the world. It is a cause of nearly half a million deaths worldwide. Medical marijuana has helped many people recover from the deadly disease.

In the view of the situation, many different countries have also relaxed their laws on the use of cannabis and cannabis related products. COVID-19 very badly affected economies all around the world. Tax revenues generated by the sales of Cannabis might help lift the deflating economies.

DANGERS of Cannabis

Cannabis consists of two main compounds; CBD (Cannabinol) and THC (Tetrahydrocannabinol). While CBD is responsible for relaxing the brain and nerves, THC is responsible for the ‘buzz’ or ‘high feeling’. THC acts on specific receptors in brain cells and slowly deteriorates our brain.

However, Cannabis is an extremely useful drug if used in measured quantities. It is highly effective in Treating Pain With Zero Side-Effects.

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Cannabis May Be A Cure For Various Cancers

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Various innovative and developing countries have acknowledged the healing benefits of cannabis. It has been used in herbal remedies for centuries. Studies have also shown that they can actively help in the treatment of various cancers.

Source: Arizona Natural Selections

The Study

A number of studies have been conducted to study medicinal uses of cannabis. These also include people going through a cancer treatment. The studies suggest that marijuana can help in controlling the following:

Pain: Like opioids, marijuana works as one of the strongest pain relievers while treating patients living with cancer related pain. In addition to this, it may have anti-inflammatory effects that may help in curing pain.

Neuropathy: It is a medical term for nerve damage and is a frequent problem of chemotherapy and other cancer treatments. It’s characteristics includes a feeling of weakness, numbness, itching and a flaming sensation in the hands and feet. Hence, marijuana provides comfort and liberation of pain resulting from neuropathy.

Nausea and Vomiting: Nausea and vomiting are one of the side effects of chemotherapy. Many cancer patients encounter these side effects. Dronabinol is a synthetic cannabinoid which is approved by U.S. Food and Drug Administration for such kind of side effects. Various other examinations clearly indicates that medical marijuana plays a valuable role in curing nausea and vomiting.

Also Read: Medicinal Cannabis Legalized In Australia But People Opt For Illegal Sources

Anorexia or Cachexia: It is the medical term for the loss of appetite. Cachexia is the phenomenon of unintended loss of weight specially the loss of lean muscle and fat often followed by tiredness and a reduction in functional abilities.

FDA has also approved the synthetic cannabinoid Dronabinol for anorexia associated with acquired immune deficiency syndrome (AIDS). However, there are not enough researches that indicates the effectiveness of medicinal marijuana in controlling of these symptoms. But, marijuana may increase the intake of food in HIV patients.

Anti-neoplastic: Lab and animal testing shows that marijuana might be productive in slowing down or preventing the development of certain tumors.

Conclusion Of The Study

However, this study shows that marijuana can be safe and secure in treating cancer but it does not indicates that marijuana will help in curing the disease. Hence, people must not only depend on marijuana for treatment while keeping themselves away from conventional medical care for cancer.

Side Effects Of Marijuana

Although THC may assist in reducing nausea and other symptoms, it also has a few side effects such as inability to think clearly or focus. The long-term side effects include psychotic disorders such as schizophrenia, depression or a person may become a bipolar patient. Additionally, respiratory disorders such as chronic bronchitis may also develop.

There is no as such evidence available that supports the use of medicinal marijuana. Moreover, since marijuana is considered as an illegal drug so the research and investigation on its medical use has been greatly reduced. However, interest in this field has greatly increased over the past few years. Furthermore, it requires a lot of studies in order to comprehend the benefits posed by marijuana to improve symptoms and standard of life for cancer patients.

Also Read: Family Hospitalized After Mistaking Marijuana Leaves For Fenugreek 

When To See Your Doctor?

It is necessary to maintain an honest discussion with your doctor about any sorts of symptoms you are experiencing. As a result, this will allow your doctor to decide whether there is a need to prescribe medicinal marijuana for treatment or not.

There are numerous ways of consuming marijuana such as vaporization, edibles, pills or oils. If your doctor prescribes medical marijuana as a treatment for you then you must also discuss the most suitable form for you based on the availability of the products in your region. Moreover, it’s essential to remember that the side effects vary from person to person based on the product you have used.

Hence, you must also discuss the side effects you’re experiencing with your doctor in order to prevent further complications.

 

 

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Cannabis Might Be The Cure For COVID-19

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With a continuous spread of COVID-19 all around the world, researchers are looking into various possibilities for its treatment. As a result, two Canadian researchers suggest that strong strains of cannabis might play an effective role in treating Coronavirus.

Source: Lab Manager

Researchers

The researchers Olga and Igor Kovalchuck have reportedly been generating and carrying out trials on a novel cannabis strain for years. As soon as the outburst of COVID-19 pandemic, both of them started to put in a lot of efforts on how the strain might be used in the treatment of Coronavirus.

The duo’s work was published in an April issue of the online medical journal Preprints.

The Study

According to various reports, these researchers have discovered that extracts from cannabis, also known as marijuana, might help in the fight against the Coronavirus infection. They used artificial three dimensional miniatures of oral, intestinal and airway tissues.

Also Read: First Wednesdays Introduces U.K Cannabis Ecosystem

High CBD extracts of cannabis sativa were found to regulate ACE-2 gene expression and ACE-2 protein levels. The results of the study shows that the extracts of hemp containing high levels of CBD provides assistance to block proteins. (The ACE-2 receptors, which works as the “entry point” for Coronavirus into host cells in the body).

Apart from this, the strain have other benefits too. This can prevent the growth and accumulation of the virus once it has already entered into someone’s body.

Angiotensin-Converting Enzyme 2

The scientific community have basically recognized Angiotensin-converting enzyme 2 (ACE-2) as a receptor needed for the entry of SARS-CoV-2 into human cells.

According to Dr Igor Kovalchuk, CEO of Pathway Rx and holder of a Health Canada License for Cannabis Research, “Our initial findings warrant further investigation but it’s possible that medical cannabis products could become a safe adjunct therapy for the treatment of COVID-19.”

Also Read: 3000 Cannabis Plants Seized At Lake Elsinore Residencies 

However, Pathway Rx has screened more than thousand categories of cannabis sativa. Among them, only a few have shown medicinal characteristics. Additionally, the research agency is further appealing for funds in order to support its efforts to sermonize COVID-19.

Other Drugs Tested For Treatment Against COVID-19

The COVID-19 pandemic began in Wuhan, China last year in December. It has now spread all around the world and has infected approximately more than 4.8 million people. It has further taken 3,00,000 lives.

Several drugs are going through various trials for the treatment of Coronavirus. This includes anti-malaria drug Hydroxychloroquine, anti-HIV medicines and others.

However, this is still a hypothesis instead of a confirmed fact. But if offers a little hope for the future. If they are able to prove this theory, the next measure would be to produce the successful strain into medical formations. The medical department will then use it for prevention and treatment.

 

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