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Can Marijuana Treat Depressive Disorders?

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Medical marijuana is getting the same popularity as a magic pill, if not more. With a little research, scientists have collected a lot of evidence on the wonders it can do including mental health problems.

According to a study last year, people who used marijuana reported to have fewer symptoms of depression. Smoking marijuana alleviates signs of anxiety and depressive attacks within a short time. However, the effect does not work in the long run, and the symptoms appear again. This study appears online in the Journal of Affective Disorders.

Scientists from Washington State University in Pullman conducted this study. They examined data from around 12000 people through a mobile application. The application enables medical marijuana consumers to keep track of apparent symptoms before the substance use. They can also note down the outcomes in the form of signs after cannabis use. This way, they can compare the two results, and the researchers used the comparison for their study.

There is little research on the effects of marijuana on depressive disorders. Most of the research is linking with the properties of the active compound tetrahydrocannabinol which is present in the substance. According to scientists from the study, the subjects under interest did not consume the product in lab premises. It was instead an observational study that allowed the users to consume the product in their comfort zone instead of a laboratory.

Marijuana with the adjusted ratio is helpful in managing the symptoms

Marijuana with a ratio adjusted according to higher cannabidiol (CBD) and low tetrahydrocannabinol (THC) was efficient in reducing depression-related symptoms. However, the long term effects turned out to be perplexing. They found that the signs in the long term aggravated.

In the case of anxiety, there was no fixed ratio required as in depression to alleviate the symptoms. Ten puffs were enough to lower the levels of stress in the users.

An important factor to acknowledge is the importance of both active compounds in easing the symptoms. CBD and THD both are equally significant in treating depressive disorder if the ratio is correct.

Gender wise, women encountered lesser symptoms of anxiety and depression in using marijuana in comparison to men. All these results point towards the fact that proper awareness and guidance to people is the need of the hour so that they can benefit from the substance.

medical marijuana for depression

Marijuana can also alleviate symptoms of chronic stress

There has been another research in 2015 in the University of Buffalo’s Research Institute on Addictions. The scientists examined that endocannabinoids are associated with better moods in people. These are chemicals present in the brain and activate the same receptors as tetrahydrocannabinol.

On rodent testing, the scientists concluded that endocannabinoids are not produced in sufficient quantities in people suffering from chronic stress. THC could fill up the scarcity and hence could be used as a substitute for the chemical. Not only that, it might help normalize the chemical function and reduce depressive disorder symptoms.

Are the effects only short term?

A little evidence is present to prove that cannabis can be used as an antidepressant. However, there are some significant loopholes in this evidence. According to a phenomenon Amotivational Syndrome, people who consume marijuana lose empathic skills. Moreover, they tend to isolate themselves and have a lesser than average capability to carry out daily activities.

So even though marijuana shortly treats the apparent signs of depressive disorders, it lacks the tendency to provide a permanent cure. Also, scientists suggest adopting to vaping as it is less harmful than smoking.

There is a dire need for all organizations and researching bodies to sit on a table and have an extended framework for research. With more states legalizing the medical marijuana laws and decriminalizing possession, there is a hope that scientists will dive deeper into looking multi dimensionally into the problem. This way they will be able to find ways to improvise the potential of the substance for the treatment of depression.

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Are You Planning To Get A Cannabis Business License In Connecticut? Read To Begin Planning

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Cannabis Connecticut

The cannabis business in Connecticut is likely to develop new opportunities for people. It will be beneficial for the state and the public. The business community is excited to begin marijuana involving operations as the state has legalized pot for recreational purposes.

 

Entrepreneurs, investors, and growers; are developing business plans and gathering information to obtain a license to begin cannabis businesses. Specific licensing criteria and application deadlines have not been established by the authorities yet. However, Connecticut law provides some guidance to entrepreneurs and investors to begin planning about their pot business. 

 

Applicants For Cannabis Business Licenses In Connecticut

 

According to the law, two groups of applicants can apply to access a pot businesses license. The two groups are the Social Equity Group and general applicants. 

ALSO READ: Cannabis Giant – Canopy Growth Losses Mega Money And Execs Earns Bonuses

A Social Equity Group may consist of an individual or multiple individuals. It must be 65 percent owned and controlled by an individual or individuals of specific qualities. The individual(S) in this group can be from an average household with a revenue of less than 300% of the state median household income and had been taxpayers.  

 

An individual with residency in a disproportionately impacted area for not less than five of ten years immediately preceding the application can apply as a Social Equity Group applicant. An applicant with 65% ownership and who had been a resident of a disproportionately impacted area for not less than nine years before turning 18 can also apply. 

 

The Connecticut Department of Consumer Protection will not award a license to any lottery applicant who has two or more licenses, of the same type at the same time of lottery until June 30, 2025. An applicant may submit as many applications as desire. It is because the legislature has not set any limitations on the number of applications by an applicant.

 

License Types And Application Expenses

 

Cannabis business licenses are of seven types. General applicants and Social Equity Group; both can apply for any license type. The retailer and hybrid retailer license, lottery entry fee is $500, the fee for provision license is $5000 and renewing this type of license costs $25000. 

 

The lotter entry fee, provision license fee, and renewal fee of a cultivator license type are $1000, $25000, and $75000, respectively. The third type of license is Micro-cultivator. The entry fee, fee for provision license, and final fee for Micro-cultivator are $250, $500, and $1000, respectively. 

 

Product manufacturer license, entry fee is $750, its provision fee is $5000, and the final charge is $25000. Cannabis food and beverage manufacturer license, entry fee is $250, provision fee is $1000, and renewal or final fee is $5000. The product packager license type, entry fee costs $500, the provision fee costs $5000, and the final fee is $25000.

 

Are There Any Discounts 

 

Individuals who qualify as Social Equity Group applicants will receive a 50% discount from the Connecticut government for the first three renewal cycles. Moreover, people who meet qualifications will get substantial financial savings. Doing so will allow them to begin operations effectively. 

ALSO READ: Explosion Caused By Invercargill Couple During Cannabis Oil Production

 

Individuals who have medical cannabis business licenses and desire to transform into another license type can do so after paying some fee. 

 

If an applicant desires to convert their medical cannabis dispensary license into a hybrid retailer license, they must pay $1000000 as a fee. Likewise, an existing medical pot producer can convert their license, to include recreational marijuana production by paying $3000000. 

 

Already established cannabis businesses in Connecticut will not receive a 50% discount even if they belong to the Social Equity Group. However, they can become eligible for discounted license fees if they show dedication to creating equity joint ventures. 

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Cannabis Giant – Canopy Growth Losses Mega Money And Execs Earns Bonuses

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Cannabis industry growth

Canopy Growth is a cannabis and cannabinoid-based consumer-product company. The marijuana giant experiences huge losses CA$1.7 billion, and there have been some profits. Ups and downs in sales and profits are part of trade and business activities. 

 

Canopy Growth executives received more than 4 million Canadian dollars (equivalent to $3.2 million) in cash. According to a regulatory filing, executives receive bonuses after making solid progress in the year. The company lose CA$1.7 billion and reduces its labor force by laying off hundreds of workers. 

 

Compensation Packages Of Ontario-based Cannabis Company

 

According to Smith Falls, the annual general meeting was scheduled for September 14 via webcast. Executive compensation figures were disclosed before the meetings. The compensation packages for executives consist of salaries and bonuses. 

ALSO READ: Is Tobacco Industry Shifting To Cannabis

 

Canopy Growth company also provides long-term and short-term incentives as it is their policy. Five of the executives of the cannabis giant company will be receiving bonuses as short-term incentives. The company grants long-term bonuses annually in March. But in 2021, these were awarded on June 9. 

 

The LTI bonuses were not awarded in the total compensation table. However, they were issued after the end of the fiscal year. The proxy noted that the company is determined to fix the regular timing of annual LTI grants. Moreover, from the beginning of Fiscal 2022, annual LTI grants will occur in June of each year. In Fiscal 2021 no LTI awards were granted by the cannabis company.

 

Canopy Growth Performance Measures 

 

The world-leading marijuana company uses four measures to evaluate performance. Depending upon performance related to corporate objectives, executives get cash rewards or annual bonuses. 

 

Performance in maintaining free cash flow has the highest weighting in the four performances measures. It weighs 50%. Net revenue weightage is 20%, adjusted EBITDA contributes 20 percent, and an individualized objective contributes 10% in performance measures. 

 

In the fiscal 2021 year, the company could not meet its net revenue and adjusted EBITDA. However, the company was bale to meet goals for free cash flow. Free cash flow was half the shortfall the company predicted. 

 

Adjusted EBITDA is a measure of profitability, and in the 2021 fiscal year, the adjusted EBITDA came in a negative $258 million. The cannabis company had an objective of negative $246 million. There were slight changes in net revenue and other performance measures. 

 

Bonuses Allocation

 

Canopy Growth announces to give David Klein a cash bonus worth CA$2.2 million. David Klein is the CEO of the company. The chief financial officer of the marijuana company Mike Lee will receive a cash bonus of CA$579,000. 

ALSO READ: Everyone Wants More Cannabis At Cheap Price

 

Rade Kovacevic is the president and chief product officer and will receive from the cannabis company a short-term cash bonus worth CA$659000. The chief commercial officer of the pot company is Julious Grant. The company is awarding Julious Grant a bonus of CA$360,000 in cash. Phil Shaer is the legal officer of Canopy Growth and will be receiving a cash bonus of Canadian dollar three hundred and fifty-one thousand. 

 

According to the proxy statement, the executive leadership team put great efforts and performed well in reducing financial losses, maintaining success. Teamwork to help the company revise CPG strategy and improve financially. Dealing with the challenges of the environmental changes caused by the pandemic situation was difficult for everyone. Continuing to work efficiently and perform well in difficult times was a remarkable effort of the company. 

 

Four members of the executive leadership team, received a modest increase in their salary, between CA$14000 to CA$25000. The CEO David Klein will not be receiving any raise in income. He will continue to get CA$1.2 million salaries as the CEO of Canopy Growth cannabis company.

Originally covered on: mjbizdaily

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Can Cannabis-based Drug Treat Brain Tumors? UK Trials Designed To Discover More

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Marijuana cannabis effects on brain

Brain research studies have occurred previously, but the UK-based trial will analyze cannabis-based drug efficacy in treating brain tumors. Thus, this clinical project is different, and its findings can be life-changing for many patients. 

 

The University of Birmingham is planning to coordinate a UK trial. The aim of organizing this trial is to analyze the efficacy of Sativex in treating the most aggressive brain tumors. Sativex is a marijuana-based drug.

ALSO READ: Is Tobacco Industry Shifting To Cannabis

Within the United Kingdom, the NHS has allowed only limited medical marijuana products. Doing so controls the use of medical pot products. It also makes it difficult for all patients to get access to pot-based treatment programs. 

 

Brian tumors are very aggressive sometimes and may remain silent for multiple years. Treatment of such tumors is complex. But there are possibilities of treating them with the marijuana-based drug. The UK trial will help to determine efficacy, safety, and chances of treating neurological tumors. 

 

The UK Trial On Cannabis-Based Drug

 

The Brain Tumor Charity is funding the new phase II trial. The trial involving cannabis-based drugs is going to launch at 15 NHS hospitals. The phase I study in 27 patients has shown promising results, and researchers are hopeful about effectiveness in the new phase II trial. 

 

Glioblastoma is an aggressive brain tumor that has an average survival of fewer than ten months. The treatment is not much effective, and its progression occurs at a faster rate. Due to multiple reasons, patients suffering from glioblastoma are unable to continue living a healthy life. 

 

In the UK trial, patients will receive Sativex together with their chemotherapy. The trial will determine whether or not the cannabis-based drug Sativex increases the survival rate of patients with brain tumors. 

 

Phase I Cannabis Involving UK Trial 

 

Sativex is a marijuana-based drug, it is an oral spray that contains cannabinoids THC and CBD. This drug has shown promising results in phase I trial and improves the condition of people fighting with glioblastoma.

ALSO READ: Explosion Caused By Invercargill Couple During Cannabis Oil Production

The cannabis-based drug has a good efficacy profile in treating patients with multiple sclerosis. During the phase one trial, Sativex was effective when given chemotherapy to patients suffering from a brain tumor. 

 

During the phase, I study the number of patients on Sativex who were observed to live longer than those patients, that were on placebo. However, sufficient data from the phase I study, to show survival impact was not gathered. 

 

Phase II UK Trial To Determine Pot Role In Treating Brain Tumors

 

The phase II trial is called ARISTOCRAT. This trial will continue to research and investigate by observing patients receiving cannabis-based medicine for three years. A placebo group will also be under observation during this time.

 

Professor Susan Short is leading the phase II trial at the University of Leeds. The Cancer Research UK Clinical Trials Unit at the University of Birmingham also co-ordinate the study.

More than 230 patients with brain tumors are to gather from all across the UK nations to conduct the trial. The procedure will begin in early 2022, and the process of funds collection is ongoing.

 

Due to the pandemic, the income of the Brain Tumour Charity decreases by 25 percent last year. As a result, they had to discontinue their research grant funding program. Today the organization launched an appeal to raise £450,000 to open the trial involving the cannabis-based drug.

 

Glioblastomas are one of the most common and aggressive forms of brain cancer. Each year in England alone, about 2200 people are diagnosed with it, with the lowest survival rate. 

 

Moreover, glioblastomas are fast-growing, highly diffusive, have poor boundaries, and extend to multiple parts of the brain. After intensive treatments, including surgery, these brain tumors develop again and again in different areas.

 

Cannabis-based drug effectiveness can give hope and relief in treating and prolonging the life of patients with these aggressive tumors. It is essential to conduct the trial as soon as possible. 

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