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Can Cannabis Treat Pancreatic Cancer?

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In new research, Dana Farber Cancer Institute and affiliate researchers have suggested a new way to treat pancreatic cancer. The research says that there can be a treatment for resistant pancreatic cancer with the help of a compound in marijuana. The compound is not CBD or THC. Instead, it is cannabis flavonoid.

Flavonoid is a chemical compound common in plants and fruits. It gives a vibrant color to the plant and has lots of health-related benefits.

Pancreatic cancer is a deadly form of cancer. In fact, it is the second major cause of cancer-related deaths. There are very low chances of survival. Only 20 percent of the patients survive for about a year and 8% for about 5 years. It is because pancreatic cancer cells have a greater capacity to develop resistance against treatment.

Pancreatic cancer is a very aggressive form of cancer also approaches other body parts within days. Treatment options include surgery, chemotherapy, immunotherapy, and radiation therapy. Surgery can only help at an initial stage diagnosis. Advanced stage cancer is usually defiant to these methods. There is a dire need for a treatment to improve both the quality and quantity of the patient’s life.

Investigations conducted at Dana Farber Cancer Institute

In an experiment, the researchers induced pancreatic cancer cell to rats in both vivo and vitro conditions. Later, they introduced them a cannabis flavonoid FBLO3G. It is a flavonoid extracted from Cannflavin B found in Cannabis Sativa strain. They used the method of flash chromatography to extract it from the plant.

The investigators used the modern technique of smart radiotherapy biomaterials to inject the medicine.

They published online their findings in the journal Frontiers in Oncology. Mice which were not treated died in about 20 days. About 30 to 50% of the mice exposed to radiations and FBLO3G survived for more than 40 days.

Also read- Chronic Cannabis Use and Liver Cancer

The measurements of the tumor through digital Vernier caliper, after treatment, showed a marked reduction in the size of the tumor. Cannabis flavonoid attacked both local and metastatic tumor cells. Moreover, it also reduced the number of cancer cells in other parts of the body.

What can these component do?

There is a great possibility that use of FBLO3G can increase the life of expectancy patients and may treat pancreatic cancer.

The overall discussions about the healing quality of cannabis usually revolve around CBD and THC. Both of the cannabinoids work effectively with endocannabinoid mechanism found in the body.

Although the compound FBLO3G has been extracted from the same source, it has some entirely different qualities. It is non-cannabinoid and non-psychoactive component. Unlike CBD and THC, it has nothing to do with the endocannabinoid receptor system of the body.

Cannabis flavonoid is found in very low concentration in a plant. To extract a considerable amount for experimentation is another hindrance for investigation. however, scientists are trying to synthesize it artificially in the laboratory.

The study’s authors strongly recommend the need for further research in this field. This way, their findings are applicable clinically to ease the life of patients by the end of the year 2020. It would require human involvement clinically for better verification of results.

 

 

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Cannabis

lllinois: Largest Recreational Marijuana Dispensary Opens in South Beloit

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Illinois is one of the states where the use of recreational marijuana is legal. People of Illinois can have up to 5 plants at home for medical use. They can also have commercially licensed plants for recreational use as well.

This Monday, Illinois saw the opening of its largest recreational marijuana dispensary. The dispensary is located at about 5000 feet from a proposed casino. It is the wonderful location of the dispensary that could improve a lot of sales prospects and also bring new ones. However, it is also only a 1000 feet south of the Wisconsin border, a state where cannabis consumption is illegal. 

What it means to the state

According to the city’s mayor, the development prospects that come with the store are to write home about. Moreover, the sales tax revenue from the dispensary will be like icing on a cake. 

Visible from heavily used Interstate 90, the Sunnyside South Beloit dispensary (7,208-square-foot) is located at 7000 First Ranger Road. Mayor Ted Rehl is very optimistic about the prospects that come with the dispensary. He’s called this dispensary ‘a gift to South Beloit’ at 12 various levels.

Mayor Rehl’s humble estimate is that the dispensary would generate sales tax revenues of about $100,000 per year, for at least the first 7 years. Then depending on the situation, if recreational marijuana is still a no-go for Wisconsin, the revenue could climb up to $700,000 a year. 

The dispensary employs 35 full-time workers and is open from 9 a.m. to 9 p.m. every day. While smokable flower cannabis is the dispensary’s number one product, edibles and vaporizers get their due share of popularity too. 

 The main reason why the dispensary is so important is its demographics. With Wisconsin not so far away and a casino to be made, the dispensary promises to be a major attraction for people, pouring in from all over Illinois and Wisconsin. Mayor Rehl says that a lot of restaurants have already approached him regarding opening their businesses in the acreage. This not only opens up new doors of income to the state, it also promises to be a prime business hub.  

Marijuana and its recreational use

The recreational use of marijuana in Illinois has been legal since the 1st of January. However, medical use was approved way back in 2015. Since then, more than 131,000 residents have acquired medical marijuana cards.

When recreational use of marijuana became legal in the state, the Rockford store was stormed by people from all over Illinois. People waited for hours in lines to get legal recreational marijuana.

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Image Credit: nbcchicago.com

However, over time the sales process became more and more fluid. With the opening of the new dispensary in South Beloit, one can go in and make a purchase in just about 5 minutes.

In May 2020, Illinois made $44 million through the sale of recreational pot alone. This not only marked record sales but also generated a lot of revenue for the state in the form of sales tax.

However, cannabis has been a taboo topic until recent times. Now, cannabis has numerous medical uses. In fact, cannabis has been found effective in treating some COVID-19 patients. Moreover, cannabis also helps in pain-relieving as well. Some studies have also revealed that smoking marijuana boosts memory as well. 

With the opening of the Sunnyside marijuana dispensary, it looks like things will start to get even better for the state of Illinois as it attracts more and more investment.

 

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Industrial Cannabis: Uzbek-French Company to Launch Cultivation Project

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The cannabis market is ever-growing despite facing many hurdles including the stigma attached to it. With countries worldwide currently battling with the deadly coronavirus, the cannabis industry has undergone its share of struggles. This included the delay of multiple decisions and plans for the expansion of cannabis businesses. However, Uzbekistan took a step towards the case of industrial cannabis.

Dunyo News Agency has reported that ABM ORGANICS LLC, an Uzbek-French business, has planned the launch of its cultivation project with cannabis. They have planned to launch this project in the Khorezm region.

The company has planned to focus on the technical hemp, in the cannabis cultivation project that they are planning to launch. The technical hemp is a kind derived from the plant species, Cannabis sativa

The agreement held 2 authorities

  • Marafon Finlex The Uzbek company
  • Opal & Co – The French company

The two distinct companies signed the agreement for the organization of this company. Following this agreement, they became stockholders, on July 12.

Moreover, the signing ceremony which consisted of the respective documents of the organization was held in Paris, France. The new company is now on the hunt for further growth points in the current economy.

Furthermore, the Uzbekistan government had declared previously, the growth of cannabis for industrial purposes. However, in the declaration, they included the addition of specific drug content in cannabis.

The drug content was up to 0.2% tetrahydrocannabinol. This specific substance can be addictive, which is why the Uzbekistan government set a specific ration, in their previous declaration.

Industrial cannabis in the green economy

Researchers believe for cannabis to potentially be a major part of the green economy in the upcoming years, with the inclusion of France. The cannabis plant has its own benefits and requires almost 5 times less hydration in comparison to cotton. Moreover, studies acknowledge cannabis as a wasteless material.

The growth and cultivation of such plants can be a state monopoly in Uzbekistan. Many of the types of cannabis are currently used in paper, pharmaceutical, light, and several other industries.

COVID-19 in Uzbekistan

Recently, the government announced its plans for the reopening of many businesses during the mid of the previous month. The businesses included cafes and restaurants, kindergartens, and clothing retailers. Moreover, the government announced the resumption of bus routes in a few provinces. These provinces had a lesser risk of the coronavirus, with the least active cases.

Moreover, the government divided the nation into color-coded zones

  • Red
  • Yellow
  • Green

The government labeled these 3 regions as such on the basis of the rate of the active COVID-19 cases. However, even these regions entertained the resumption of soccer games and domestic tourism. Nevertheless, the declaration allowed no spectators to be present during soccer games. The government also resumed domestic flights and train transportation.

The Uzbekistan government had started to ease its lockdown restrictions to a large extent last month. This allowed many businesses to resume their operations as well. A month later, they took a step towards the cultivation of industrial cannabis, to expand the present cannabis industry.

While this is still an initial stage and much is yet to be done, it is a big step towards the eventual launch. The government has dealt with the coronavirus situation and lockdown very effectively.

The global lockdown has effectively caused an economic shutdown worldwide and Uzbekistan is no exception. However, many reporters also consider this launch to be a potential attempt to regain the lost economy. If so, many news agencies are waiting for the next step of this project and what it could mean for the cannabis industry in Uzbekistan.

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Long Term Use of Cannabis Could Affect Your Social Behavior, Here’s Why

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While there’s no denying the fact that cannabis has tons of medical benefits, extended exposure to it could have serious social behavioral repercussions.

In a nutshell, long term use of cannabis affects the ability of astrocytes to manufacture food for neurons from glucose. This reduced food production compromises on the neural function, which appears to have adverse effects on the person’s behavior.

The way long term cannabis use alters behavior appears to have a direct link with the cannabinoid function. While it is mostly observation and researchers know of no concrete mechanism yet, cannabis consumption could lead to reduced social interactions and withdrawal.

A deeper understanding of the cannabinoid receptors could prove fruitful in determining the relationship between cannabis and social behavior.

The role of cannabinoids

The role cannabinoids play is much more important than ever since some of these receptors are also present on the mitochondrial membrane. ‘Mitochondrion is the powerhouse of the cell’, is a statement almost everyone is well familiar with. If something were to happen to the mitochondria inside the cells, it could very well reflect on the person’s behavior.

Also read: Cannabis Maybe a Cure For Various Cancers

Mitochondria metabolize glucose into lactate, which neurons use as food. The main psychoactive compound in cannabis is THC. A better understanding of the relationship between the two could open doors to new possibilities.

Observations in mice reveal that if astrocytes are exposed to THC for an extended period of time, the cannabinoid receptors present in them start a chain of reactions that in turn lead to glucose metabolism dysfunction.

Therefore, there’s less available ‘food’ for astrocytes. This is like operating some heavy machinery with dry cells from a TV remote. Observations made suggest that this lack of ‘food’ has a direct impact on the subject’s behavior.

Moreover, in extreme cases, exposure to THC hampered social interactions for up to 24 hours.

While uncontrolled use of cannabis could be dangerous, controlled use with appropriate observations could very well be used to deal with some behavioral problems more easily and effectively.

The debate over therapeutic cannabis is yet again a hot topic. A better understanding of cannabis’ effects on the human body could help in finding the optimal solution.

However, for now, a simple rule to keep in mind, excess of everything is bad.

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